方案
≥88% (enzymatic)
杂质
≤12% water
溶解性
0.1 M NaOH: 10 mg/mL, slightly hazy, orange
SMILES字符串
NC1=NC(=O)C2=C(NCC(CNc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=N2)N1
InChI
1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
InChI key
OZRNSSUDZOLUSN-LBPRGKRZSA-N
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一般描述
通过二氢叶酸还原酶 (DHFR) 将膳食叶酸转化为四氢叶酸的中间产物。在细菌中，二氢叶酸是 7,8-二氢蝶酸由二氢叶酸合成酶生成。
其他说明
Assay of dihydrofolate reductase
法规信息
新产品
此项目有
Dihydrofolate reductase: a coupled radiometric assay.
P Reyes et al.
Methods in enzymology, 122, 360-367 (1986-01-01)
Samuel Thompson et al.
eLife, 9 (2020-07-24)
Protein mutational landscapes are shaped by the cellular environment, but key factors and their quantitative effects are often unknown. Here we show that Lon, a quality control protease naturally absent in common E. coli expression strains, drastically reshapes the mutational
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