38100
3,5-Diiodo-L-thyronine
≥96.0% (calc. based on dry substance, NT)
别名:
3,5-Diiodo-4-(4-hydroxyphenoxy)-L-phenylalanine, 3,5-T2, O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine
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关于此项目
经验公式（希尔记法）:
C15H13I2NO4
化学文摘社编号:
分子量:
525.08
Beilstein:
2707891
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.26
方案
≥96.0% (calc. based on dry substance, NT)
旋光性
[α]20/D +28±2°, c = 1% in ethanol/1 M HCl (2:1)
杂质
≤5% water
mp
255-260 °C (dec.)
储存温度
2-8°C
SMILES字符串
N[C@@H](Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1)C(O)=O
InChI
1S/C15H13I2NO4/c16-11-5-8(7-13(18)15(20)21)6-12(17)14(11)22-10-3-1-9(19)2-4-10/h1-6,13,19H,7,18H2,(H,20,21)/t13-/m0/s1
InChI key
ZHSOTLOTTDYIIK-ZDUSSCGKSA-N
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其他说明
Preparation of high specific activity labeled triiodothyronine for radioimmunoassay
危险声明
预防措施声明
危险分类
Aquatic Chronic 3
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
M.R.A. Pillai et al.
Radiochem. Radioanal. Lett., 47, 257-257 (1981)
Roberto Mangiullo et al.
Biochimica et biophysica acta, 1797(2), 233-240 (2009-11-03)
Besides triiodothyronine (T3), 3,5-diiodo-L-thyronine (T2) has been reported to affect mitochondrial bioenergetic parameters. T2 effects have been considered as independent of protein synthesis. Here, we investigated the effect of in vivo chronic T2 administration to hypothyroid rats on liver mitochondrial
Alessio Rochira et al.
Biochimica et biophysica acta, 1831(12), 1679-1689 (2013-08-21)
Thyroid hormone 3,5,3'-triiodo-l-thyronine (T3) is known to affect cell metabolism through both the genomic and non-genomic actions. Recently, we demonstrated in HepG2 cells that T3 controls the expression of SREBP-1, a transcription factor involved in the regulation of lipogenic genes.
Alessandro Cavallo et al.
Journal of bioenergetics and biomembranes, 43(4), 349-357 (2011-07-09)
Short-term effects of 3,5-L-diiodothyronine (T(2)) administration to hypothyroid rats on F(o)F(1)-ATP synthase activity were investigated in liver mitochondria. One hour after T(2) injection, state 4 and state 3 respiration rates were noticeably stimulated in mitochondria subsequently isolated. F(o)F(1)-ATP synthase activity
Ira J Goldberg et al.
Endocrinology, 153(11), 5143-5149 (2012-09-06)
Although studies in vitro and in hypothyroid animals show that thyroid hormone can, under some circumstances, modulate the actions of low-density lipoprotein (LDL) receptors, the mechanisms responsible for thyroid hormone's lipid-lowering effects are not completely understood. We tested whether LDL
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