38100
3,5-Diiodo-L-thyronine
≥96.0% (calc. based on dry substance, NT)
别名:
3,5-Diiodo-4-(4-hydroxyphenoxy)-L-phenylalanine, 3,5-T2, O-(4-Hydroxyphenyl)-3,5-diiodo-L-tyrosine
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关于此项目
经验公式（希尔记法）:
C15H13I2NO4
化学文摘社编号:
分子量:
525.08
UNSPSC Code:
41116107
NACRES:
NA.26
PubChem Substance ID:
EC Number:
213-867-7
Beilstein/REAXYS Number:
2707891
MDL number:
InChI key
ZHSOTLOTTDYIIK-ZDUSSCGKSA-N
InChI
1S/C15H13I2NO4/c16-11-5-8(7-13(18)15(20)21)6-12(17)14(11)22-10-3-1-9(19)2-4-10/h1-6,13,19H,7,18H2,(H,20,21)/t13-/m0/s1
SMILES string
N[C@@H](Cc1cc(I)c(Oc2ccc(O)cc2)c(I)c1)C(O)=O
assay
≥96.0% (calc. based on dry substance, NT)
optical activity
[α]20/D +28±2°, c = 1% in ethanol/1 M HCl (2:1)
impurities
≤5% water
mp
255-260 °C (dec.)
storage temp.
2-8°C
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Other Notes
Preparation of high specific activity labeled triiodothyronine for radioimmunoassay
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
M.R.A. Pillai et al.
Radiochem. Radioanal. Lett., 47, 257-257 (1981)
Roberto Mangiullo et al.
Biochimica et biophysica acta, 1797(2), 233-240 (2009-11-03)
Besides triiodothyronine (T3), 3,5-diiodo-L-thyronine (T2) has been reported to affect mitochondrial bioenergetic parameters. T2 effects have been considered as independent of protein synthesis. Here, we investigated the effect of in vivo chronic T2 administration to hypothyroid rats on liver mitochondrial
Alessandro Cavallo et al.
Journal of bioenergetics and biomembranes, 43(4), 349-357 (2011-07-09)
Short-term effects of 3,5-L-diiodothyronine (T(2)) administration to hypothyroid rats on F(o)F(1)-ATP synthase activity were investigated in liver mitochondria. One hour after T(2) injection, state 4 and state 3 respiration rates were noticeably stimulated in mitochondria subsequently isolated. F(o)F(1)-ATP synthase activity
Alessio Rochira et al.
Biochimica et biophysica acta, 1831(12), 1679-1689 (2013-08-21)
Thyroid hormone 3,5,3'-triiodo-l-thyronine (T3) is known to affect cell metabolism through both the genomic and non-genomic actions. Recently, we demonstrated in HepG2 cells that T3 controls the expression of SREBP-1, a transcription factor involved in the regulation of lipogenic genes.
Alessandro Cavallo et al.
PloS one, 8(1), e52328-e52328 (2013-01-12)
Growing evidence shows that, among triiodothyronine derivatives, 3,5 diiodo-L-thyronine (T(2)) plays an important role in energy metabolism and fat storage. In the present study, short-term effects of T(2) administration to hypothyroid rats on fatty acid oxidation rate and bioenergetic parameters
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