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Merck
CN

38266

铁草氨菌素 E 来源于抗生素链霉菌

suitable for microbiology, ≥95%

别名:

1,12,23-三羟基-1,6,12,17,23,28-六氮杂环三十三烷-2,5,13,16,24,27-异己酮铁(III) 络合物

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关于此项目

经验公式(希尔记法):
C27H45FeN6O9
化学文摘社编号:
分子量:
653.53
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
41171614
MDL number:
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sterility

non-sterile

Quality Level

assay

≥95% (HPLC), ≥95%

form

powder

loss

≤6% loss on drying

application(s)

environmental
food and beverages, microbiology

storage temp.

2-8°C

suitability

Salmonella spp.

SMILES string

[Fe+3].[O-]N1CCCCCNC(=O)CCC(=O)N([O-])CCCCCNC(=O)CCC(=O)N([O-])CCCCCNC(=O)CCC1=O

InChI

1S/C27H45N6O9.Fe/c34-22-10-14-26(38)32(41)20-8-3-6-18-30-24(36)12-15-27(39)33(42)21-9-2-5-17-29-23(35)11-13-25(37)31(40)19-7-1-4-16-28-22;/h1-21H2,(H,28,34)(H,29,35)(H,30,36);/q-3;+3

InChI key

MZFKJKOHYACYNT-UHFFFAOYSA-N

General description

The ferrioxamines are basically metabolic products produced by the actinomycetes, and are characterised as ferrioxamines A, B, C, D 1, D2, E, F and G. Generally all ferrioxamines are trihydroxamates and the deferrioxamines are either linear or cyclic (D2 and E).
Scientifically proven supplement for culture media improves detection of Salmonella, Enterobacter sakazakii and Yersinia enterocolitica .

Ferrioxamine E from Streptomyces antibioticum is a siderophore which facilitates the supply of iron (III), an essential trace element, to bacteria involved in food poisoning, including Salmonella, Enterobacter saka-zakii and Yersinia enterocolitica. It promotes rapid growth by reducing the lag phase in culture media and reactivates dormant bacteria. Use of ferrioxamine E can permit rapid detection of low bacterial cell counts, even from dry products like spices and tea after long storage periods. It is an essential component of quality control efforts in the food industry.

Ferrioxamine E is often used in Buffered Peptone Water, the medium recommended by the ISO-Norms for Enterobacteriacea. Ferrioxamine E also improves the motility of Salmonella, which helps to improve the identification by semisolid selective motility media like SIM, MRSV, DIASSALM or SMS. Ferrioxamine E does not improve growth of Escherichia coli, Shigella, Proteus, Providencia and Morganella species; a feature that makes it a semi-selective compound. The recommended concentration of Ferrioxamine E to promote bacterial growth is between 5 and 200 ng/mL

Application

在预增菌肉汤和增菌肉汤培养基中加入铁草氨菌素 E 显著改善了从人为或天然污染食品中对沙门氏菌的回收率。


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Viable but nonculturable (VBNC) bacteria describes cells that cannot be normally cultured however, “resuscitation” of these cells can be mediated by a physical and different kind of chemical stimuli.

Microbiological assessment of bacteria found in spices, a potent source for food spoilage and pathogens.


I Berner et al.
Biology of metals, 1(1), 51-56 (1988-01-01)
Several strains of the enterobacterial group Erwinia herbicola (Enterobacter agglomerans) were screened for siderophore production. After 3 days of growth in a low-iron medium, all strains studied produced hydroxamate siderophores. The retention values of the main siderophore during thin-layer chromatography
Bradley L Bearson et al.
Microbial pathogenesis, 48(6), 214-219 (2010-03-17)
Salmonella enterica serovar Typhimurium (S. Typhimurium) responds to the catecholamine, norepinephrine by increasing bacterial growth and enhancing motility. In this study, iron with or without the siderophore, ferrioxamine E also enhanced bacterial motility. Iron-enhanced motility was growth-rate dependent, while norepinephrine-enhanced
R Reissbrodt et al.
Applied and environmental microbiology, 66(9), 4128-4130 (2000-08-31)
Storage of Salmonella enterica serovar Typhimurium strains in soil and water microcosms resulted in loss of culturability on standard plating media. Prior incubation in buffered peptone water supplemented with ferrioxamine E markedly extended the time that bacteria were recoverable by



全球贸易项目编号

货号GTIN
853113002504027269100711
15106-5G04061832641195
38266-3MG-F04061831962956
38266-9MG-F04061831963014