41866
(S)-(+)-7,8-Dihydrokavain
analytical standard
别名:
(6S)-5,6-Dihydro-4-methoxy-6-(2-phenylethyl)-2H-pyran-2-one, 7,8-Dihydrokawain, Dihydrokavain, Marindinin
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关于此项目
经验公式（希尔记法）:
C14H16O3
化学文摘社编号:
分子量:
232.28
UNSPSC Code:
85151701
NACRES:
NA.24
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
15362
产品名称
(S)-(+)-7,8-Dihydrokavain, analytical standard
InChI key
VOOYTQRREPYRIW-LBPRGKRZSA-N
SMILES string
COC1=CC(=O)O[C@@H](CCc2ccccc2)C1
InChI
1S/C14H16O3/c1-16-13-9-12(17-14(15)10-13)8-7-11-5-3-2-4-6-11/h2-6,10,12H,7-9H2,1H3/t12-/m0/s1
grade
analytical standard
assay
≥98.0% (HPLC)
optical activity
[α]/D 29±2°, c = 0.5 in methanol
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
impurities
≤5.0% water
application(s)
food and beverages
format
neat
storage temp.
2-8°C
Quality Level
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Karen Savage et al.
Phytotherapy research : PTR, 32(1), 3-18 (2017-11-24)
Anxiety disorders are chronic and functionally disabling conditions with high psychological stress, characterised by cognitive symptoms of excessive worry and focus difficulties and physiological symptoms such as muscle tension and insomnia. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter within the
J Friese et al.
Planta medica, 64(5), 458-459 (1998-08-05)
The mode of action of the kava pyrones, kavain, dihydrokavain and dihydromethysticin on the specific binding of [3H]-batrachotoxinin-A 20-alpha-benzoate to epitope 2 of voltage-dependent Na+ channels was investigated by performing saturation experiments in the presence and absence of these kava
K K Smith et al.
Psychopharmacology, 155(1), 86-90 (2001-05-26)
Piper methysticum extract (kava kava) possesses numerous therapeutic properties, but it is unknown which of its principle constituents (kavalactones) subserve such effects. This experiment sought to characterize the putative anxiolytic properties of P. methysticum extract and its six principle kavalactones
Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro.
Johanna Weiss et al.
Drug metabolism and disposition: the biological fate of chemicals, 33(11), 1580-1583 (2005-07-30)
Root extracts from kava-kava (Piper methysticum G. Forst) are clinically used for the treatment of anxiety and restlessness. Due to reported cases of liver toxicity, kava-kava extracts were withdrawn from the market in several countries in 2002. Because the efflux
Michael P Pollastri et al.
Chemical biology & drug design, 74(2), 121-128 (2009-06-23)
There is a substantial unmet need for new classes of drugs that block TNF-alpha-mediated inflammation, and particularly for small molecule agents that can be taken orally. We have screened a library of natural products against an assay measuring TNF-alpha secretion
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