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Merck
CN

45673

Sigma-Aldrich

红霉素

≥95.0% (NT)

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关于此项目

经验公式(希尔记法):
C37H67NO13
化学文摘社编号:
分子量:
733.93
Beilstein:
75279
EC 号:
MDL编号:
UNSPSC代码:
51101500
PubChem化学物质编号:
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方案

≥95.0% (NT)

旋光性

[α]20/D −75±4°, c = 2% in ethanol

mp

133-135 °C

作用机制

protein synthesis | interferes

SMILES字符串

CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O

InChI

1S/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30-,31+,32-,34+,35-,36-,37-/m1/s1

InChI key

ULGZDMOVFRHVEP-RWJQBGPGSA-N

基因信息

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一般描述

Chemical structure: macrolide

生化/生理作用

作用机制: 红霉素通过在转肽步骤中抑制延伸起作用,特别是通过结合细菌70S rRNA复合物的50S亚单位来抑制氨酰从A位点到P位点的易位。

抗菌谱:该产品可以抗革兰氏阴性和革兰氏阳性细菌。

其他说明

通过结合到核糖体上抑制细菌蛋白合成;在细菌中可诱导红霉素抗性

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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H. Teraoka
Umschau in Wissenschaft Und Technik, 77, 347-347 (1977)
Inducible erythromycin resistance in bacteria.
B Weisblum
British medical bulletin, 40(1), 47-53 (1984-01-01)
Steven A Rogers et al.
Antimicrobial agents and chemotherapy, 54(5), 2112-2118 (2010-03-10)
2-aminoimidazoles are an emerging class of small molecules that possess the ability to inhibit and disperse biofilms across bacterial order, class, and phylum. Herein, we report the synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating
A Mereu et al.
Bioorganic & medicinal chemistry letters, 16(22), 5801-5804 (2006-09-20)
The synthesis of a new class of 9-(S)-dihydroerythromycin derivatives and their anti-inflammatory activity on in vivo PMA assay are described. Modifying the desosamine sugar on the C-3' amino group, it was possible to differentiate between anti-biotic and anti-inflammatory action. The
Xiaodong Xu et al.
Bioorganic & medicinal chemistry letters, 15(4), 883-887 (2005-02-03)
Novel C6-carbamate ketolides with C2-fluorination and C9-oximation have been synthesized. The best compounds in this series displayed MIC values of 0.03-0.12 microg/mL against streptococci containing erm and mef resistance determinants and 2-4 microg/mL against Haemophilus influenzae. Several compounds also showed

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