46908
磺胺索嘧啶
VETRANAL®, analytical standard
别名:
4-氨基-N-(2,6-二甲基-4-嘧啶基)苯磺酰胺, N1-(2,6-二甲基嘧啶-4-基)磺胺
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关于此项目
经验公式（希尔记法）:
C12H14N4O2S
化学文摘社编号:
分子量:
278.33
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
208-204-3
Beilstein/REAXYS Number:
261305
MDL number:
InChI key
YZMCKZRAOLZXAZ-UHFFFAOYSA-N
InChI
1S/C12H14N4O2S/c1-8-7-12(15-9(2)14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
SMILES string
Cc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(C)n1
grade
analytical standard
product line
VETRANAL®
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
mp
242-243 °C (lit.)
application(s)
clinical testing
format
neat
Quality Level
General description
Chemical structure: sulfonamide
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
Legal Information
VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
ppe
dust mask type N95 (US), Eyeshields, Gloves
S P Boom et al.
The Journal of pharmacy and pharmacology, 45(7), 614-617 (1993-07-01)
To investigate whether dogs are able to excrete acetylated drugs by active transport, the plasma kinetics and renal excretion of the N4-acetyl metabolites of sulphasomidine and sulphadimethoxine were studied in the beagle dog after a rapid intravenous bolus injection. Two
Lack of oxidative pathways in the metabolism of sulphisomidine by the turtle Pseudemys scripta elegans.
T B Vree et al.
Journal of veterinary pharmacology and therapeutics, 12(4), 459-462 (1989-12-01)
O Solberg et al.
Acta pathologica et microbiologica Scandinavica. Section B, Microbiology, 89(4), 267-270 (1981-08-01)
Four strains of Neisseria meningitidis were studied during serial passage. From two strains which originally were sulfonamide resistant, variants developed that had altered susceptibility to sulfonamides. One of the variants became relatively highly sulfonamide-sensitive, the other exhibited merely reduced sulfonamide
H Van Gogh et al.
Research in veterinary science, 48(2), 152-157 (1990-03-01)
The influence of gestation on the pharmacokinetics of four sulphonamides was studied in goats before, during and after pregnancy. Similar doses were given as intravenous boluses of 50 mg kg-1 each. Results were compared with those of non-pregnant goats to
T B Vree et al.
Pharmaceutisch weekblad. Scientific edition, 6(4), 150-156 (1984-08-24)
Sulfisomidine, sulfamethomidine, sulfadimethoxine and their corresponding N4-acetyl derivatives were administered to man. The percentages of acetylation and deacetylation and those of protein binding, the half-lives of elimination and the apparent and true renal clearance values were measured. No acetylation phenotype
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