concentration
8-11% S
impurities
≤15% water
cation traces
Na: 7-8%
General description
褐藻糖胶是一种富含岩藻糖的硫酸多糖，从几种棕色海藻分离而来。
polysaccharide, consists predominantly of sulfated L-fucose
Biochem/physiol Actions
对褐藻糖胶的研究发现它具有广泛的生物活性，包括抗肿瘤和抗血管生成活性、免疫调节、抗炎、抗凝血、抗血栓形成和抗氧化活性。 褐藻糖胶诱导巨噬细胞活化，随后激活促分裂原活化蛋白激酶（MAPK），并导致自然杀伤细胞增殖。 褐藻糖胶作为非选择性选择素阻断剂起作用，已被证明可诱导细胞凋亡并抑制血管生成。
Preparation Note
by a modification of the procedure of W.A.P. Black et al., J.Sci.Food.Agr. 3, 122 (1952)
Other Notes
Probe of polysaccharide binding to proacrosin
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R M Williams et al.
FEBS letters, 270(1-2), 168-172 (1990-09-17)
Sulphated polysaccharides and zona pellucida glycoproteins have been shown to bind non-enzymatically to proacrosin, the protein found within the acrosomal vesicle of mammalian spermatozoa. The mechanism of this interaction has been investigated using 125I-fucoidan to probe purified ram sperm proacrosin.