49431
二氯乙酸 溶液
suitable for DNA synthesis, 3% in methylene chloride
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关于此项目
经验公式（希尔记法）:
C2H2Cl2O2
化学文摘社编号:
分子量:
128.94
PubChem Substance ID:
UNSPSC Code:
12161700
Beilstein/REAXYS Number:
1098596
MDL number:
Concentration:
3% in methylene chloride
Grade:
synthesis grade
SMILES string
OC(=O)C(Cl)Cl
InChI
1S/C2H2Cl2O2/c3-1(4)2(5)6/h1H,(H,5,6)
InChI key
JXTHNDFMNIQAHM-UHFFFAOYSA-N
grade
synthesis grade
concentration
3% in methylene chloride
technique(s)
DNA synthesis: suitable
impurities
≤0.01% water
density
1.335 g/mL at 20 °C
Gene Information
human ... ALDH1A1(216), PDK1(5163)
rat ... Pdk1(116551)
General description
经过 1μm 过滤器过滤
Application
用于亚磷酸三酯法合成寡核苷酸时 5′-保护基裂解的试剂。适用于 Milligen 7500 合成仪，或作为三氯乙酸更温和的酸性替代物。
signalword
Danger
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Lact. - Repr. 1B - Skin Irrit. 2 - STOT SE 3
target_organs
Central nervous system
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
Haihua Xiao et al.
Chemical communications (Cambridge, England), 48(87), 10730-10732 (2012-09-27)
A multifunctional hybrid platinum(IV) prodrug, which consists of both the mitochondria-targeting drug DCA and the DNA-crosslinking drug cisplatin, was synthesized and tethered to a carrier polymer to further self-assemble into micelles for intracellular delivery.
Yong Won Choi et al.
Cancer letters, 346(2), 300-308 (2014-02-01)
To investigate sensitization of metformin-cytotoxicity, cancer cells were treated with dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK). Metformin-cytotoxicity was mainly dependent on glucose availability and reducing power generated by pentose phosphate pathway, whereas DCA cotreatment enhanced metformin-cytotoxicity via
Toshimitsu Ohashi et al.
International journal of cancer, 133(5), 1107-1118 (2013-02-20)
The activation of oncogenic signaling pathways induces the reprogramming of glucose metabolism in tumor cells and increases lactic acid secretion into the tumor microenvironment. This is a well-known characteristic of tumor cells, termed the Warburg effect, and is a candidate
Jae Mo Park et al.
Neuro-oncology, 15(4), 433-441 (2013-01-19)
The metabolic phenotype that derives disproportionate energy via glycolysis in solid tumors, including glioma, leads to elevated lactate labeling in metabolic imaging using hyperpolarized [1-(13)C]pyruvate. Although the pyruvate dehydrogenase (PDH)-mediated flux from pyruvate to acetyl coenzyme A can be indirectly
Mehdi D Esrafili
Journal of molecular modeling, 18(12), 5005-5016 (2012-06-28)
A theoretical study was performed to examine hydrogen and halogen bonds properties in gas phase and crystalline dichloroacetic acid (DCAA). The specific pattern of O-H∙∙∙O, C-H∙∙∙O, HCl, Cl∙∙∙O and Cl∙∙∙Cl interactions in DCAA dimers is described within the quantum theory
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