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50430

Gly-Sar

Name: Gly-Sar
Brand: SIAL

puriss., ≥99.0% (T)

别名:

甘氨酰肌氨酸

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线性分子式:

NH₂CH₂CON(CH₃)CH₂COOH

化学文摘社编号:

29816-01-1

分子量:

146.14

EC Number:

249-875-2

UNSPSC Code:

12352200

PubChem Substance ID:

24873363

Beilstein/REAXYS Number:

1768450

MDL number:

MFCD00038193

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grade

puriss.

assay

≥99.0% (T)

mp

198-202 °C (dec.)

SMILES string

CN(CC(O)=O)C(=O)CN

InChI

1S/C5H10N2O3/c1-7(3-5(9)10)4(8)2-6/h2-3,6H2,1H3,(H,9,10)

InChI key

VYAMLSCELQQRAE-UHFFFAOYSA-N

Gene Information

human ... SLC15A1(6564)

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Beta- and gamma-di- and tripeptides as potential substrates for the oligopeptide transporter hPepT1.

Ina Hubatsch et al.

Journal of medicinal chemistry, 50(21), 5238-5242 (2007-09-25)

The hPepT1-mediated transport properties of a series of 11 synthesized beta- and gamma-peptides have been studied in Caco-2 cells. The results show that several of the compounds interact with the peptide transporter, but only two beta-dipeptides act as substrates and

Influence of overexpression of efflux proteins on the function and gene expression of endogenous peptide transporters in MDR-transfected MDCKII cell lines.

Zhiying Wang et al.

International journal of pharmaceutics, 441(1-2), 40-49 (2012-12-25)

The objective of this study is to delineate whether overexpression of human efflux transporters (P-gp, MRP2, and BCRP) in transfected MDCK cells affect the functional activities, and gene and protein expression of endogenous influx peptide transporter system (PepT). Real-time PCR

OAT1 and OAT3: targets of drug-drug interaction between entecavir and JBP485.

Qinghan Xu et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 650-657 (2013-01-15)

Entecavir and JBP485 (a dipeptide) exhibit the antihepatitis activities and it is possible for the two drugs to be coadministered in the treatment of hepatitis. We aimed to elucidate whether entecavir was a substrate of OAT1, OAT3, OCT, and PEPT1

Pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats.

Jian Cang et al.

Drug metabolism and pharmacokinetics, 25(5), 500-507 (2010-09-30)

To investigate the pharmacokinetics and mechanism of intestinal absorption of JBP485 in rats, the pharmacokinetics of JBP485 were investigated in vivo both intravenously and orally. The effects of glycylsarcosine (Gly-Sar) on the uptake and transepithelial transport of JBP485 were examined

Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice.

Dilara Jappar et al.

Drug metabolism and disposition: the biological fate of chemicals, 39(12), 2250-2257 (2011-09-02)

This study evaluated the in vivo absorption and disposition of glycylsarcosine (GlySar), after escalating oral doses, in wild-type and peptide transporter 1 (Pept1) knockout mice. [(3)H]GlySar was administered to mice at doses of 1, 10, 100, 1000, and 5000 nmol/g

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全球贸易项目编号

货号	GTIN
850303P-500MG	04061835229925
850303P-25MG	04061835229918

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