50510
18β-甘草次酸
purum, ≥97.0% (T)
别名:
乌拉尔酸, 亚葡萄糖酸, 甘草次酸
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关于此项目
经验公式（希尔记法）:
C30H46O4
化学文摘社编号:
分子量:
470.68
EC Number:
207-444-6
UNSPSC Code:
12352115
PubChem Substance ID:
Beilstein/REAXYS Number:
2229654
MDL number:
grade
purum
assay
≥97.0% (T)
optical activity
[α]20/D +165±3°, c = 1% in chloroform
mp
292-295 °C (lit.)
SMILES string
CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@@]34C)C(O)=O
InChI
1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21-,22-,23+,26+,27-,28-,29+,30+/m0/s1
InChI key
MPDGHEJMBKOTSU-YKLVYJNSSA-N
Gene Information
human ... HSD11B1(3290), HSD11B2(3291)
rat ... Hsd11b1(25116), Hsd11b2(25117)
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Ran You et al.
Journal of medicinal chemistry, 56(5), 1984-1995 (2013-02-05)
Fifteen novel derivatives of glycyrrhetinic acid (GA) were synthesized and evaluated for anti-inflammatory activities. It was found that the introduction of 1-en-3-one and 9(11),12-diene and 2,20-dinitrile functionalities into the scaffold of GA led to the discovery of potent compound 19
Stuart Trenholm et al.
Nature neuroscience, 16(2), 154-156 (2013-01-15)
Moving objects can cover large distances while they are processed by the eye, usually resulting in a spatially lagged retinal response. We identified a network of electrically coupled motion-coding neurons in mouse retina that act collectively to register the leading
Li Zhang et al.
International journal of pharmaceutics, 441(1-2), 654-664 (2012-11-03)
Glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate was synthesized as a carrier for intravenous administration of paclitaxel (PTX), which combined hyaluronic acid (HA) and glycyrrhetinic acid (GA) as the active targeting ligands to liver tumor. In the present study, physicochemical characteristics, cellular
Qian Shi et al.
PloS one, 7(9), e44921-e44921 (2012-10-03)
Glycyrrhetic acid (GA) exerts synergistic anti-asthmatic effects via a β₂-adrenergic receptor (β₂AR)-mediated pathway. Cholesterol is an important component of the structure and function of lipid rafts, which play critical roles in the β₂AR-Gs-adenylate cyclase (AC)-mediated signaling pathway. Owing to the
R Termei et al.
Experimental cell research, 319(12), 1839-1851 (2013-04-13)
The mechanisms that mediate acute exacerbations in chronic inflammatory diseases are not understood. As IL-8 is a potent chemoattractant for neutrophils in acute inflammatory lesions, we investigated the role of fibroblast-mast cell interactions in short-term IL-8 release. Human gingival fibroblasts
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