50872
灰黄霉素
from Penicillium griseofulvum, ≥95% (HPLC)
别名:
(2S)-trans-7-Chloro-2′,4,6-trimethoxy-6′-methylspiro(benzofuran-2[3H],1′-[2]cyclohexene)-3,4′-dione
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关于此项目
经验公式（希尔记法）:
C17H17ClO6
化学文摘社编号:
分子量:
352.77
EC Number:
204-767-4
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
95226
InChI
1S/C17H17ClO6/c1-8-5-9(19)6-12(23-4)17(8)16(20)13-10(21-2)7-11(22-3)14(18)15(13)24-17/h6-8H,5H2,1-4H3/t8-,17+/m1/s1
InChI key
DDUHZTYCFQRHIY-RBHXEPJQSA-N
SMILES string
ClC1=C(O[C@@]2(C(OC)=CC(C[C@H]2C)=O)C3=O)C3=C(OC)C=C1OC
biological source
Penicillium griseofulvum
assay
≥95% (HPLC)
optical activity
[α]20/D +355±5°, c = 1% in DMF(lit.)
mp
216-220 °C
antibiotic activity spectrum
fungi
storage temp.
−20°C
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signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Repr. 1B - Skin Sens. 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Mads H Rønnest et al.
Journal of medicinal chemistry, 52(10), 3342-3347 (2009-05-01)
Griseofulvin was identified as an inhibitor of centrosomal clustering in a recently developed assay. Centrosomal clustering is an important cellular event that enables bipolar mitosis for cancer cell lines harboring supernumerary centrosomes. We report herein the synthesis and SAR of
Nida N Farshori et al.
Bioorganic & medicinal chemistry letters, 20(6), 1933-1938 (2010-02-23)
The long-chain alkenoic acid hydrazides (1a-d) on reaction with phenylisocyanate and phenylthiocyanate gave their corresponding semicarbazides (2a-d) and thiosemicarbazides (4a-d), which on further refluxing with POCl(3) and Ac(2)O yielded corresponding 1,3,4-oxadiazoles (3a-d) and thiadiazoles (5a-d), respectively. The structure elucidation of
Hatem A Abdel-Aziz et al.
European journal of medicinal chemistry, 44(12), 4985-4997 (2009-09-29)
The reaction of 2-oxo-N-arylpropanehydrazonoyl chlorides 3a-e with 3-methyl-2-benzofurancarboxylic acid hydrazide (7) furnished N-(aryl)propanehydrazonoyl chlorides 8a-e. X-Ray of 8c revealed the (1Z,2E) configuration of structure 8. Nucleophilic substitution reaction of 8a or 8d with piperidine resulted in the formation of 1-(piperidin-1-yl)-N(2)-arylamidrazones
Mari Sithambaram Karthikeyan et al.
European journal of medicinal chemistry, 43(1), 25-31 (2007-05-25)
A series of 2,4-dichloro-5-fluorophenyl containing 1,3,4-oxadiazoles (10 and 11) were synthesized by POCl3 cyclization of 2,4-dichloro-5-fluorobenzoyl hydrazide (4) and 2-(2,4-dichloro-5-fluorophenyl)cinchoninyl hydrazide (8) with aryloxyacetic acids (9). The structures of newly synthesized compounds were characterized by spectral and elemental analyses. All
Vinod Mathew et al.
European journal of medicinal chemistry, 42(6), 823-840 (2007-03-03)
Several 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole and their dihydro analogues were synthesized from hetero aromatic acids and hetero aromatic aldehydes, respectively, by microwave-assisted dry media and conventional methods. Elemental analysis, IR, (1)H NMR, (13)C NMR and mass spectral data elucidated the structures of all
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