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关于此项目
经验公式(希尔记法):
C30H42N2O9
化学文摘社编号:
分子量:
574.66
PubChem Substance ID:
UNSPSC Code:
51101500
Beilstein/REAXYS Number:
4834067
MDL number:
assay
≥98.0% (HPLC)
solubility
acetonitrile: 0.2 mg/mL, clear, yellow
antibiotic activity spectrum
viruses
mode of action
enzyme | inhibits
storage temp.
−20°C
SMILES string
CO[C@H]1C[C@H](C)[C@@H](OC)C2=CC(=O)C=C(NC(=O)\C(C)=C\C=C[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1OC)C2=O
InChI
1S/C30H42N2O9/c1-16-10-9-11-23(37-5)28(41-30(31)36)18(3)12-17(2)27(40-8)24(38-6)13-19(4)26(39-7)21-14-20(33)15-22(25(21)34)32-29(16)35/h9-12,14-15,17,19,23-24,26-28H,13H2,1-8H3,(H2,31,36)(H,32,35)/b11-9-,16-10+,18-12+/t17-,19-,23-,24-,26+,27+,28-/m0/s1
InChI key
MCAHMSDENAOJFZ-BVXDHVRPSA-N
General description
Chemical structure: benzenoid
Biochem/physiol Actions
An antibiotic that inhibits protein tyrosine kinase. Herbimycin A is a potent inhibitor of angiogenesis.
Other Notes
Inhibitor of protein-tyrosine kinases
法规信息
新产品
此项目有
C M Queiroz et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 41(5), 403-410 (2008-06-12)
Intrahippocampal administration of kainic acid (KA) induces synaptic release of neurotrophins, mainly brain-derived neurotrophic factor, which contributes to the acute neuronal excitation produced by the toxin. Two protein tyrosine kinase inhibitors, herbimycin A and K252a, were administered intracerebroventricularly, in a
Shuya Kasai et al.
Bioscience, biotechnology, and biochemistry, 74(1), 36-43 (2010-01-09)
The aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by dioxin and related xenobiotics. Although the activation of AhR is inhibited by tyrosine kinase inhibitors, the molecular mechanism has not been clarified. In the current study, the
Akane Harima et al.
Hematology (Amsterdam, Netherlands), 13(4), 236-243 (2008-09-18)
Fibronectin (FN) is thought to play an important role in various aspects of hematopoiesis through binding to very late antigen (VLA)-4 and VLA-5. Little is known, however, about the effects of FN on the proliferation of B cell progenitors. In
Svenja Beckmann et al.
The Journal of biological chemistry, 286(49), 42325-42336 (2011-10-21)
Cellular protein-tyrosine kinases play key roles in signal transduction processes in eukaryotes. SmTK4 was the first Syk kinase identified in a parasite and found to be tissue-specifically transcribed in the gonads of adult Schistosoma mansoni. Functional analyses confirmed its role
Alexander Epshtein et al.
Archives of virology, 154(1), 55-63 (2008-12-11)
Expression of the E6 oncoprotein of human papillomavirus (HPV) 16 in primary human keratinocytes (PHKs) was previously shown to significantly reduce apoptosis. This could be due to increased cell adhesion. Adhesion ability was tested by seeding cells on tissue culture
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