53302
组胺 二盐酸盐
tested according to Ph. Eur.
别名:
组胺二盐酸盐, 2-(4-咪唑)乙胺 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C5H9N3 · 2HCl
化学文摘社编号:
分子量:
184.07
EC Number:
200-298-4
UNSPSC Code:
12352209
PubChem Substance ID:
Beilstein/REAXYS Number:
3624116
MDL number:
agency
tested according to Ph. Eur.
assay
≥98.5%
mp
249-252 °C (lit.)
application(s)
pharmaceutical (small molecule)
SMILES string
Cl[H].Cl[H].NCCc1c[nH]cn1
InChI
1S/C5H9N3.2ClH/c6-2-1-5-3-7-4-8-5;;/h3-4H,1-2,6H2,(H,7,8);2*1H
InChI key
PPZMYIBUHIPZOS-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
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Application
Histamine dihydrochloride was employed as pharmaceutical substance to investigate the orthogonality of the chromatographic systems, required for the separation of impurities from the active substance and from each other in drugs with an unknown impurity profile. It may be used in the preparation of imidazolium-linked cyclophane.
Biochem/physiol Actions
内源性 H1 和 H2 组胺受体激动剂;可活化一氧化氮合成酶;有效的血管舒张剂。
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Y Lurie et al.
Journal of viral hepatitis, 9(5), 346-353 (2002-09-13)
Interferon- (IFN-)alpha is currently the standard of care treatment for patients with chronic hepatitis C virus (HCV) infection. A significant part of the benefit of IFN-alpha in chronic hepatitis C is believed to be related to the activation of lymphocytes
Vibrational spectra and assignments of histamine dication in the solid state and in solution.
Collado JA and Ramirez FJ.
Journal of Raman Spectroscopy, 31(10), 925-931 (2000)
E Van Gyseghem et al.
Journal of chromatography. A, 988(1), 77-93 (2003-03-22)
To define starting conditions for the development of methods to separate impurities from the active substance and from each other in drugs with an unknown impurity profile, the parallel application of generic orthogonal chromatographic systems could be useful. The possibilities
Jolanta B Perz et al.
Future oncology (London, England), 4(2), 169-177 (2008-04-15)
Histamine dihydrochloride is a vasoactive biogenic amine. It inhibits the reactive oxygen species formation in monocytes via histamine H2 receptors and protects natural killer and T cells from oxidative damage. Histamine has the potential to optimize cytokine-induced activation of T
F Donskov et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 13(3), 441-449 (2002-05-09)
Histamine inhibits formation and release of monocyte/macrophage-derived reactive oxygen metabolites and thereby protects natural killer (NK) and T cells against oxidative inhibition. Efficacy and safety of histamine, when given in combination with interleukin-2 (IL-2) and interferon-alpha (IFN-alpha), were evaluated in
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