53787
卡拉洛尔
analytical standard
别名:
1-(咔唑-4-氧基)-3-(异丙基氨基)-2-丙醇, 4-(2-羟基-3-异丙胺基-丙氧基)咔唑
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关于此项目
经验公式（希尔记法）:
C18H22N2O2
化学文摘社编号:
分子量:
298.38
Beilstein:
3620576
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
NACRES:
NA.24
等级
analytical standard
质量水平
方案
≥98.5% (HPLC)
技术
HPLC: suitable
gas chromatography (GC): suitable
solid phase extraction (SPE): suitable
mp
133-137 °C
应用
forensics and toxicology
pharmaceutical (small molecule)
veterinary
包装形式
neat
储存温度
2-8°C
SMILES字符串
CC(C)NCC(O)COc1cccc2[nH]c3ccccc3c12
InChI
1S/C18H22N2O2/c1-12(2)19-10-13(21)11-22-17-9-5-8-16-18(17)14-6-3-4-7-15(14)20-16/h3-9,12-13,19-21H,10-11H2,1-2H3
InChI key
BQXQGZPYHWWCEB-UHFFFAOYSA-N
一般描述
Supelco MIP SPE 滤筒标准品。更多信息，请参阅 Supelco 文献 T407075、T706030 和 T706025。
应用
Carazolol may be used as a reference standard for the determination of the analyte:
- In swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
- In animal tissues by high-performance liquid chromatography with electrochemical detection.
Commission Regulation (EU) No 37/2010 of 22 December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
包装
Bottomless glass bottle. Contents are inside inserted fused cone.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Sid Topiol et al.
Biochemical pharmacology, 78(1), 11-20 (2009-05-19)
G-protein-coupled receptor (GPCR) proteins [Lundstrom KH, Chiu ML, editors. G protein-coupled receptors in drug discovery. CRC Press; 2006] are the single largest drug target, representing 25-50% of marketed drugs [Overington JP, Al-Lazikani B, Hopkins AL. How many drug targets are
Tomonaga Ozawa et al.
Bioorganic & medicinal chemistry, 19(17), 5231-5237 (2011-08-09)
We examined CH/π hydrogen bonds using an ab initio fragment molecular orbital (FMO) method, combined with the CHPI program, to evaluate complexes of active (bound with agonist 1) and inactive (bound with inverse agonist 2) β2 adrenergic receptor (β(2)AR) states.
Tony Warne et al.
Nature, 454(7203), 486-491 (2008-07-03)
G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets. Here we report the 2.7 A resolution crystal structure of a beta(1)-adrenergic receptor in complex with the high-affinity antagonist cyanopindolol. The modified
Stefano Costanzi
Journal of medicinal chemistry, 51(10), 2907-2914 (2008-04-30)
The publication of the crystal structure of the beta2-adrenergic receptor (beta2-AR) proved that G protein-coupled receptors (GPCRs) share a structurally conserved rhodopsin-like 7TM core. Here, to probe to which extent realistic GPCR structures can be recreated through modeling, carazolol was
Determination of residues of carazolol and a number of tranquilizers in swine kidney by high-performance liquid chromatography with ultraviolet and fluorescence detection.
Keukens HJ and Aerts MML
Journal of Chromatography A, 464, 149- 161 (1991)
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