56810
2-亚氨基硫烷 盐酸盐
≥98.0% (TLC)
别名:
2-亚氨基硫杂环戊烷 盐酸盐, 2-亚氨基硫烷盐酸盐 盐酸盐, 2IT, Traut 试剂
方案
≥98.0% (TLC)
mp
192-197 °C
198-201 °C (lit.)
储存温度
2-8°C
SMILES字符串
N=C1SCCC1.Cl
InChI
1S/C4H7NS.ClH/c5-4-2-1-3-6-4;/h5H,1-3H2;1H
InChI key
ATGUDZODTABURZ-UHFFFAOYSA-N
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其他说明
在蛋白质中生成可解聚的二硫键连二聚体的交联剂；多糖的硫醇化；有效的 RNA-蛋白质交联剂
法规信息
新产品
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T T el-Baradi et al.
FEBS letters, 186(1), 26-30 (1985-07-01)
Saccharomyces carlsbergensis 60 S ribosomal subunits were treated with the hetero-bifunctional crosslinking agent 2-iminothiolane and then subjected to mild UV irradiation to introduce protein-rRNA crosslinks. The major crosslinked products were identified as proteins L2, L3, L5, L19 and L23 of
R. Singh et al.
Analytical Biochemistry, 23, 114-114 (1996)
A C Alagon et al.
Biochemistry, 19(18), 4341-4345 (1980-09-02)
2-Iminothiolane, a cyclic thioimidate, is known to react readily with amino groups of proteins to give amidinated derivatives containing reactive sulfhydryl groups. In this report it will be shown that 2-iminothiolane also reacts with hydroxyl and sulfhydryl groups. Such a
Cross-linking of ribosomes using 2-iminothiolane (methyl 4-mercaptobutyrimidate) and identification of cross-linked proteins by diagonal polyacrylamide/sodium dodecyl sulfate gel electrophoresis.
J W Kenny et al.
Methods in enzymology, 59, 534-550 (1979-01-01)
Jonathan O Martinez et al.
Biomaterials, 35(37), 9824-9832 (2014-09-02)
Nanovectors are a viable solution to the formulation of poorly soluble anticancer drugs. Their bioaccumulation in the tumor parenchyma is mainly achieved exploiting the enhanced permeability and retention (EPR) effect of the leaky neovasculature. In this paper we demonstrate that
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