57240
吲哚啉
purum, ≥98.0% (GC)
别名:
2,3-二氢吲哚, 吲哚啉
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关于此项目
经验公式（希尔记法）:
C8H9N
化学文摘社编号:
分子量:
119.16
EC Number:
207-816-8
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
111915
MDL number:
grade
purum
assay
≥98.0% (GC)
form
liquid
color
clear dark brown
refractive index
n20/D 1.592
bp
220-221 °C (lit.)
density
1.063 g/mL at 25 °C (lit.)
SMILES string
C1Cc2ccccc2N1
InChI
1S/C8H9N/c1-2-4-8-7(3-1)5-6-9-8/h1-4,9H,5-6H2
InChI key
LPAGFVYQRIESJQ-UHFFFAOYSA-N
Application
用作制备以下产品的反应物：
- NOD1 诱导的核因子-κB 活化抑制剂
- 1-磷酸鞘氨醇 4 (S1P4) 受体拮抗剂
- 细胞毒性细胞周期抑制剂
- 2-氨基吡啶类
- 用于蛋白激酶 C (PKC) 成像的 PET 试剂
- 治疗糖尿病高血糖症的钠依赖性葡萄糖协同转运蛋白 2 (SGLT2) 抑制剂
- α4β2-烟碱乙酰胆碱受体选择性部分激动剂
- mGlu4 阳性变构调节剂
- 细菌生物膜抑制剂
- 血清素 5-HT6 受体拮抗剂
法规信息
新产品
此项目有
Kamalkishor P Landge et al.
The Journal of organic chemistry, 77(13), 5705-5713 (2012-06-08)
An effective method of constructing the indoline moiety via intramolecular nucleophilic ring closure of a diaryliodonium salt is described. Diacetoxyiodoarene compounds (1a-1e) were converted into intermediate Koser's reagent and coupled with arylstannanes (7-10) to form diaryliodonium salts (11a-14e). Indoline compounds
María López-Iglesias et al.
The Journal of organic chemistry, 77(18), 8049-8055 (2012-08-25)
Racemic indolines including a variety of structural motifs such as C-2 and C-3 substitutions (alkyl or aryl), cis/trans relative stereochemistry and functionalization of the aromatic ring (fluoro, methyl or methoxy groups) have been efficiently prepared through Fischer indolization and subsequent
Zhaoyang Liu et al.
Molecules (Basel, Switzerland), 18(3), 3107-3117 (2013-03-09)
A donor-acceptor (D-A) type indoline dye, D149, was used as an electron donor in solution-processed organic solar cells (OSCs). For bulk-heterojunction (BHJ) type OSCs with PC70BM as electron acceptor, the power conversion efficiency (PCE) is sensitive to the amount of
Toshiharu Noji et al.
Organic letters, 15(8), 1946-1949 (2013-04-04)
A benzyne-mediated synthesis of substituted indolines and carbazoles was developed. The reaction includes generation of benzyne using Mg(TMP)2·2LiCl as a base, cyclization, and trapping the resulting organomagnesium intermediate with an electrophile to provide a series of substituted indolines and carbazoles
Manas K Ghorai et al.
The Journal of organic chemistry, 78(8), 3867-3878 (2013-04-04)
A practical approach for the synthesis of 3-substituted indolines via regio- and stereoselective SN2-type ring-opening of 2-(2-halophenyl)-N-tosylaziridines with heteroatomic nucleophiles (O, N, and S) followed by palladium-catalyzed intramolecular C-N cyclization is reported in excellent yields (up to >99%) and enantiomeric
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