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58032

4-碘- L -苯丙氨酸

Name: 4-碘-<SC> L </SC>-苯丙氨酸
Brand: SIAL

purum, ≥96.0% (HPLC), ~1 mol/mol water

别名:

( S )-2-氨基-3-（4-碘苯基）丙酸

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关于此项目

经验公式（希尔记法）:

C₉H₁₀INO₂

化学文摘社编号:

24250-85-9

分子量:

291.09

PubChem Substance ID:

329758394

UNSPSC Code:

12352200

Beilstein/REAXYS Number:

4411317

MDL number:

MFCD00002602

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属性

grade

purum

assay

≥96.0% (HPLC)

optical activity

[α]20/D −6.5±2°, c = 1% in acetic acid: water (4:1)

impurities

~1 mol/mol water

application(s)

peptide synthesis

SMILES string

N[C@@H](Cc1ccc(I)cc1)C(O)=O

InChI

1S/C9H10INO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)/t8-/m0/s1

InChI key

PZNQZSRPDOEBMS-QMMMGPOBSA-N

说明

存储类别

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number

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Para-[(123)I]iodo-L-phenylalanine in patients with pancreatic adenocarcinoma: tumour uptake, whole-body kinetics, dosimetry.

D Hellwig et al.

Nuklearmedizin. Nuclear medicine, 47(5), 220-224 (2008-10-15)

Recently, p-[(123)I]iodo-L-phenylalanine (IPA) was clinically validated for brain tumour imaging. Preclinical studies demonstrated uptake of IPA into pancreatic adenocarcinoma suggesting its diagnostic application in patients with pancreatic tumours. The aim was to study the tumour uptake of IPA in patients

p-[123I]iodo-L-phenylalanine for detection of pancreatic cancer: basic investigations of the uptake characteristics in primary human pancreatic tumour cells and evaluation in in vivo models of human pancreatic adenocarcinoma.

Samuel Samnick et al.

European journal of nuclear medicine and molecular imaging, 31(4), 532-541 (2004-01-15)

Pancreatic cancer is associated with the worst 5-year survival rate of any human cancer. This high mortality is due, in part, to difficulties in establishing early and accurate diagnosis. Because most tumours share the ability to accumulate amino acids more

Synthesis of peptide labelled with p-iodophenylalanine which corresponds to the first amphipathic region of apolipoprotein C-I.

D R Harding et al.

International journal of peptide and protein research, 26(2), 208-213 (1985-08-01)

The amino terminal fragment (1-15) of apolipoprotein C-1, H-Thr-Pro-Asp-Val-Ser-Ser-Ala-Leu-Asp-Lys-Leu-Lys-Glu-Phe14-Gly was prepared by the solid phase method. However, the phenylalanine residue at position 14 was replaced with p-iodophenylalanine in the chemical synthesis. The preparation of t-butyloxy-carbonyl-p-iodophenylalanine is described. After completion of

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