58168
离子霉素 钙盐 来源于密团链霉菌
≥80% (HPLC)
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关于此项目
经验公式（希尔记法）:
C41H70CaO9
化学文摘社编号:
分子量:
747.07
PubChem Substance ID:
UNSPSC Code:
12352200
Beilstein/REAXYS Number:
1416163
MDL number:
SMILES string
C[C@@H]1CCC(=O)O[Ca]OC(=CC(=O)[C@@H](C)C[C@@H](C)C1)[C@H](C)C[C@H](C)C\C=C\[C@@H](C)[C@@H](O)[C@@H](C)[C@@H](O)C[C@@H]2CC[C@](C)(O2)[C@H]3CC[C@](C)(O3)[C@@H](C)O
InChI
1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-24-;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1
InChI key
WKRWUYKLUMMAKG-WYGBAUISSA-L
assay
≥80% (HPLC)
antibiotic activity spectrum
Gram-positive bacteria
mode of action
cell membrane | interferes
storage temp.
−20°C
Biochem/physiol Actions
比A23187更有效地作为Ca2+ 的移动离子载体的Ca2+ 离子载体；无荧光；用于研究Ca2+ 跨生物膜的运输；诱导胚胎皮层神经元凋亡变性。
比A23187更有效地作为Ca2+的移动离子载体的C2+ 离子载体
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Nonfluorescent ionophoric antibiotic which exhibits a greater selectivity for Ca2+ over Mg2+ than does A23187
C B Wollheim et al.
The Journal of biological chemistry, 259(4), 2262-2267 (1984-02-25)
Changes in the concentration of free cytosolic Ca2+ [( Ca2+]i), membrane potential, and immunoreactive insulin release were measured in suspensions of RINm5F cells. [Ca2+]i was monitored with the intracellularly trapped fluorescent Ca2+ indicator quin 2. Changes in membrane potential were
R Gennaro et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(5), 1416-1420 (1984-03-01)
The cytosolic concentration of free Ca2+ in bovine neutrophils was monitored by using the intracellular Ca2+ indicator quin2, 2-[[2-bis(acetylamino)-5-methylphenoxy]methyl-6-methoxy-8- bis(acetylamino)]quinoline. Neutrophils at rest have a cytosolic Ca2+ concentration of 85 +/- 5 nM, which in 2-4 min increases to 300-400
C Liu et al.
The Journal of biological chemistry, 253(17), 5892-5894 (1978-09-10)
The ionophorous properties of a new antibiotic, ionomycin, have been studied. It was found that the antibiotic is capable of extracting calcium ion from the bulk of an aqueous phase into an organic phase. The antibiotic also acts as a
Konstantin V Salojin et al.
PloS one, 9(5), e98151-e98151 (2014-05-24)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and autoimmunity has not
Katrien Pletinckx et al.
European journal of immunology, 45(2), 480-491 (2014-11-11)
Anergic T cells can survive for long time periods passively in a hyporesponsive state without obvious active functions. Thus, the immunological reason for their maintenance is unclear. Here, we induced peptide-specific anergy in T cells from mice by coculturing these cells with
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