assay
≥99.0% (NT), ≥99.0%
quality
for spectrophotometric det. of proline and thiophene
technique(s)
UV/Vis spectroscopy: suitable
ign. residue
≤0.1%
loss
≤0.5% loss on drying
mp
193-195 °C (dec.) (lit.), 201-203 °C
SMILES string
O=C1Nc2ccccc2C1=O
InChI
1S/C8H5NO2/c10-7-5-3-1-2-4-6(5)9-8(7)11/h1-4H,(H,9,10,11)
InChI key
JXDYKVIHCLTXOP-UHFFFAOYSA-N
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Other Notes
Reagent for the spectrophotometric det. of thiophene and proline
存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
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An improved method for colorimetric determination of proline with isatin.
F N Boctor
Analytical biochemistry, 43(1), 66-70 (1971-09-01)
Franco Chimenti et al.
Bioorganic & medicinal chemistry, 18(14), 5063-5070 (2010-06-29)
The present study reports on synthesis in high yields (70-99%), HPLC enantioseparation, inhibitory activity against human monoamino oxidases, and molecular modeling including 3D-QSAR studies, of a large series of (4-aryl-thiazol-2-yl)hydrazones (1-45). Most of the synthesized compounds proved to be potent
Franco Chimenti et al.
Bioorganic & medicinal chemistry, 18(15), 5715-5723 (2010-07-10)
A new series of [4-(3-methoxyphenyl)-thiazol-2-yl]hydrazyne derivatives were synthesized in good yield (71-99%) and characterized by elemental analysis and (1)H NMR studies. The compounds were assayed for their in vitro human monoamine oxidase (hMAO) inhibitory activity and selectivity and most of
Hui Lv et al.
Organic letters, 14(21), 5412-5415 (2012-10-16)
An N-heterocyclic carbene (NHC)-catalyzed annulation reaction of isatin N-Boc ketimines and enals is developed for the synthesis of spirocyclic oxindole-γ-lactams bearing one quaternary chiral center in good yields and excellent stereoselectivities (up to >20:1 dr and 99% ee).
Alexandra Gaspar et al.
Journal of medicinal chemistry, 54(14), 5165-5173 (2011-06-24)
Two series of novel chromone derivatives were synthesized and investigated for their ability to inhibit the activity of monoamine oxidase. The SAR data indicate that chromone derivatives with substituents in position 3 of γ-pyrone nucleus act preferably as MAO-B inhibitors
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