66681
4,4′-亚甲基双(2-氯苯胺)
analytical standard
别名:
2,2′-二氯-4,4′-亚甲基二苯胺, 4,4′-二氨基-3,3′-二氯二苯甲烷
等级
analytical standard
保质期
limited shelf life, expiry date on the label
技术
HPLC: suitable
gas chromatography (GC): suitable
沸点
202-214 °C/0.3 mmHg (lit.)
mp
102-107 °C (lit.)
应用
environmental
包装形式
neat
SMILES字符串
Nc1ccc(Cc2ccc(N)c(Cl)c2)cc1Cl
InChI
1S/C13H12Cl2N2/c14-10-6-8(1-3-12(10)16)5-9-2-4-13(17)11(15)7-9/h1-4,6-7H,5,16-17H2
InChI key
IBOFVQJTBBUKMU-UHFFFAOYSA-N
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一般描述
4,4′-Methylene-bis(2-chloroaniline) is an azo dye metabolite that is deemed toxic to the environment.
This compound is listed in the SVHC (Substances of very high concern) candidate list of ECHA (European Chemicals Agency)
应用
4,4′-Methylene-bis(2-chloroaniline) may be used as an analytical reference standard for the determination of 4,4′-methylene-bis(2-chloroaniline) in:
- Urine samples by high performance liquid chromatography (HPLC).
- Textile samples by HPLC coupled to tandem mass spectrometry (MS/MS) equipped with multiple reaction monitoring (MRM) mode of detection.
- Plastic multilayer food packaging materials by LC-Orbitrap-full scan-high resolution mass spectrometry (HRMS) equipped with electrospray ionization (ESI) source.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
其他说明
用于测定商品中偶氮染料所释放的芳香胺的标准品
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
警示用语：
Danger
危险分类
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Muta. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
235.4 °F - closed cup
闪点(°C)
113 °C - closed cup
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
危险化学品
此项目有
Degradability of selected azo dye metabolites in activated sludge systems.
Ekici P, et al.
Chemosphere, 44(4), 721-728 (2001)
G. Rohm et al.
GIT Labor-Fachzeit., 1080-1080 (1997)
LC-MS/MS method for the confirmatory determination of aromatic amines and its application in textile analysis.
Sutthivaiyakit P, et al.
Analytical and Bioanalytical Chemistry, 381(1), 268-276 (2005)
4,4'-Methylenebis(2-chloroaniline).
Report on carcinogens : carcinogen profiles, 11, III167-III168 (2004-01-01)
Hong-I Chen et al.
Journal of occupational health, 49(5), 389-398 (2007-10-24)
Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between
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