InChI key
YGPSJZOEDVAXAB-QMMMGPOBSA-N
InChI
1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1
SMILES string
N[C@@H](CC(=O)c1ccccc1N)C(O)=O
grade
analytical standard
assay
≥98% (HPLC)
optical activity
[α]25/D -32.5 to -28.0°, c = 0.4 in H2O
shelf life
limited shelf life, expiry date on the label
impurities
≤5.0% water
application(s)
clinical testing
format
neat
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Biochem/physiol Actions
色氨酸降解途径的关键中间物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xue Jiang et al.
International journal of immunopathology and pharmacology, 34, 2058738420950584-2058738420950584 (2020-09-24)
Indoleamine 2,3-dioxygenase (IDO) was a potential tumor immunotherapy target. IDO inhibitors showed inconsistent results in clinical trials, but no preclinical comparative study was reported. The purpose of this study was to evaluate the differences of representative IDO inhibitors (PCC0208009, INCB024360
Ahmed Sadik et al.
Cell, 182(5), 1252-1270 (2020-08-21)
Aryl hydrocarbon receptor (AHR) activation by tryptophan (Trp) catabolites enhances tumor malignancy and suppresses anti-tumor immunity. The context specificity of AHR target genes has so far impeded systematic investigation of AHR activity and its upstream enzymes across human cancers. A
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