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Kynurenic acid, a tryptophan metabolite, is a naturally occurring NMDA-receptor and an α7 nicotinic acetylcholine receptor antagonist in the human brain with preferential action at both of the glycine (Gly) binding sites of the N-methyl D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors. This implies that the compound can have a physiological interaction with glutaminergic and cholinergic neurotransmission in the brain. Kynurenic acid is reported to be found in elevated levels in the cerebrospinal fluid of patients with schizophrenia. Its anticonvulsant and neuroprotective properties are experimentally reported.

Kynurenic acid may be used as an analytical standard for the quantification of the analyte in serum samples, food and honeybee products using high-performance liquid chromatography with fluorescence detection.

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