等级
analytical standard
方案
≥98.0% (HPLC)
保质期
limited shelf life, expiry date on the label
mp
275 °C (dec.) (lit.)
应用
clinical testing
SMILES字符串
OC(=O)c1cc(O)c2ccccc2n1
InChI
1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
InChI key
HCZHHEIFKROPDY-UHFFFAOYSA-N
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一般描述
Kynurenic acid, a tryptophan metabolite, is a naturally occurring NMDA-receptor and an α7 nicotinic acetylcholine receptor antagonist in the human brain with preferential action at both of the glycine (Gly) binding sites of the N-methyl D-aspartate (NMDA) and α7 nicotinic acetylcholine receptors. This implies that the compound can have a physiological interaction with glutaminergic and cholinergic neurotransmission in the brain. Kynurenic acid is reported to be found in elevated levels in the cerebrospinal fluid of patients with schizophrenia. Its anticonvulsant and neuroprotective properties are experimentally reported.
应用
Kynurenic acid may be used as an analytical standard for the quantification of the analyte in serum samples, food and honeybee products using high-performance liquid chromatography with fluorescence detection.
其他说明
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Kynurenic acid inhibits synaptic and acidic amino acid-induced responses in the rat hippocampus and spinal cord
Ganong HA, et al.
Brain Research, 273(1), 170-174 (1983)
Determination of kynurenic acid in human serum and its correlation with the concentration of certain amino acids
Fukushima T, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 377(1-2), 174-178 (2007)
Presence of kynurenic acid in food and honeybee products
Turski PM, et al.
Amino Acids, 36(1), 75-80 (2009)
Kynurenic acid levels are elevated in the cerebrospinal fluid of patients with schizophrenia
Erhardt S, et al.
Neuroscience Letters, 313(1-2), 96-98 (2001)
More rapid and sensitive method for simultaneous determination of tryptophan and kynurenic acid by HPLC
Lan-Gan P, et al.
Clinical Biochemistry, 42(4-5), 420-425 (2009)
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