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Merck
CN

69761

3,5-二羟基-3-甲基戊酸内酯

purum, ≥96.0% (T)

别名:

(±)-3-羟基-3-甲基 δ-戊内酯, (±)-β-羟基-β-甲基-δ-戊内酯, DL-甲羟戊酸内酯

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关于此项目

经验公式(希尔记法):
C6H10O3
化学文摘社编号:
分子量:
130.14
EC Number:
211-615-0
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
80960
MDL number:
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InChI key

JYVXNLLUYHCIIH-UHFFFAOYSA-N

InChI

1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3

SMILES string

CC1(O)CCOC(=O)C1

grade

purum

assay

≥96.0% (T)

impurities

salt, none detected

mp

24-27 °C

storage temp.

2-8°C

Other Notes

Lactone of mevalonic acid which is a very important connecting link in the biosynthesis of isoprenoids

Disclaimer

can form fused mass at low temperatures

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number

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The biosynthesis of cholesterol.
G POPJAK et al.
Advances in enzymology and related subjects of biochemistry, 22, 281-335 (1960-01-01)
J.W. Porter et al.
Biosynthesis of Isoprenoid Compounds, vol. 1 and 2 null
B. Preiss, ed.
Regulation of HMG-CoA Reductase null
R. Clayton
Quart. Rev., 19, 168-168 (1965)
Martha M Monick et al.
Journal of immunology (Baltimore, Md. : 1950), 171(5), 2625-2630 (2003-08-21)
These studies demonstrate that treatment of macrophages with lovastatin, a cholesterol-lowering drug that blocks farnesylation and geranylgeranylation of target proteins, increases LPS-induced TNF-alpha production. This is reversed by the addition of mevalonate, which bypasses the lovastatin block. Examination of membrane

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