70440
1-萘酚
puriss., ≥99.0% (GC)
别名:
α-萘酚, 1-羟基萘
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关于此项目
线性分子式:
C10H7OH
化学文摘社编号:
分子量:
144.17
EC Number:
201-969-4
UNSPSC Code:
12352100
PubChem Substance ID:
Beilstein/REAXYS Number:
1817321
MDL number:
InChI key
KJCVRFUGPWSIIH-UHFFFAOYSA-N
InChI
1S/C10H8O/c11-10-7-3-5-8-4-1-2-6-9(8)10/h1-7,11H
SMILES string
Oc1cccc2ccccc12
vapor density
4.5 (120 °C, vs air)
vapor pressure
1 mmHg ( 94 °C)
grade
puriss.
assay
≥99.0% (GC)
autoignition temp.
1007 °F
expl. lim.
5 %
ign. residue
≤0.05%
bp
278-280 °C (lit.)
mp
95-97 °C
suitability
suitable for fluorescence
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General description
1-Naphthol is the hydroxyl derivative of naphthalene. It forms hydrogen bonded complexes with H2O, CH3OH, NH3 and ND3 in gas phase. Hydrogen-bond dissociation energy of these complexes has been evaluated. Its sorption by biochars (obtained from orange peels, having pyrolytic temperatures in the range of 150-700°C and designated as OP150-OP700) has been studied. It has been identified as an impurity in the active pharmaceutical ingredient (API) of duloxetine hydrochloride.
Application
1-Naphthol (Naphthalen-1-ol) may be used as a standard for the NMR, FT-IR and mass spectrometric characterization of impurities present in the Duloxetine Hydrochloride active pharmaceutical ingredient (API).3
signalword
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1A - STOT SE 2 Oral - STOT SE 3
target_organs
Kidney, Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
257.0 °F - closed cup
flash_point_c
125 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Characterization of duloxetine HCL API and its process related impurities
Karagiannidou E, et al.
International Journal of Analytical, Pharmaceutical and Biomedical Sciences, 3(2) (2014)
Baoliang Chen et al.
Chemosphere, 76(1), 127-133 (2009-03-14)
Biochars, derived from biomass, are increasingly recognized as an environmental-friendly sorbent to abate organic pollutants. Sorption variations of biochars with their pyrolytic temperatures are evaluated. Nine biochars of orange peels with different pyrolytic temperatures (150-700 degrees C, referred as OP150-OP700)
Hongbo Zhang et al.
Toxicology in vitro : an international journal published in association with BIBRA, 26(8), 1286-1293 (2012-01-24)
In vitro glucuronidation assays of diclofenac and indomethacin at pH 7.4 are biased by the instability of the glucuronides due to acyl migration. The extent of this acyl migration may be reduced significantly by performing the glucuronidation reaction at pH
Nenad Manevski et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(11), 2192-2203 (2012-08-23)
The presence of bovine serum albumin (BSA) largely modulates the enzyme kinetics parameters of the human UDP-glucuronosyltransferase (UGT) 1A9, increasing both the apparent aglycone substrate affinity of the enzyme and its limiting reaction velocity (Drug Metab Dispos 39:2117-2129, 2011). For
Ondrej Zitka et al.
Electrophoresis, 32(22), 3207-3220 (2011-10-21)
Guanosine derivatives are important for diagnosis of oxidative DNA damage including 8-hydroxy-2'-deoxyguanosine (8-OHdG) as one of the most abundant products of DNA oxidation. This compound is commonly determined in urine, which makes 8-OHdG a good non-invasive marker of oxidation stress.
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