76456
(±)-氯苯那敏 马来酸盐
pharmaceutical secondary standard; traceable to USP, PhEur and BP
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关于此项目
经验公式（希尔记法）:
C16H19ClN2 · C4H4O4
化学文摘社编号:
分子量:
390.86
EC Number:
204-037-5
UNSPSC Code:
41116000
MDL number:
agency
traceable to BP 81, traceable to Ph. Eur. C1800000, traceable to USP 1123102
mp
130-135 °C (lit.)
SMILES string
CN(C)CCC(C1=CC=C(Cl)C=C1)C2=NC=CC=C2.O=C(/C=C\C(O)=O)O
InChI
1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChI key
DBAKFASWICGISY-BTJKTKAUSA-N
Biochem/physiol Actions
H 1 组胺受体拮抗剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Anaphylactic reaction to ranitidine and dexchlorpheniramine.
C Thurot-Guillou et al.
European journal of dermatology : EJD, 17(2), 170-171 (2007-03-06)
Eef L Theunissen et al.
British journal of clinical pharmacology, 61(1), 79-86 (2006-01-05)
Previous studies have demonstrated that the antihistamines mequitazine, cetirizine and dexchlorpheniramine produce mild sedation after single doses. It is unknown, however, whether acute sedation persists after repeated dosing. Therefore, this study assessed the effects of repeated dosing of these antihistamines
Urticaria due to aloe vera: a new sensitizer?
Alberto Alvarez-Perea et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 105(5), 404-405 (2010-11-09)
A Moreno-Ancillo et al.
Allergologia et immunopathologia, 31(6), 342-344 (2003-12-13)
Carboplatin (CP) hypersensitivity reactions have been reported in nearly 12 % of patients treated with this drug. The pathophysiologic mechanisms of these reactions have not been entirely elucidated. Various hypotheses are under discussion. CP hypersensitivity reactions could be IgE-mediated, caused
O Cáceres Calle et al.
Allergologia et immunopathologia, 32(5), 306-309 (2004-10-01)
Dexchlorpheniramine (DH) is a classical or first generation antihistamine belonging to the ethanolamine group. Adverse effects related to these antihistamines are frequent, but the hypersensitivity reactions described in the literature since 1940 are exceptional. We report the case of a
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