storage temp.
−20°C
Gene Information
Bordetella pertussis Tohama I ... ptxA(2665068), ptxB(2665069), ptxC(2665408)
Application
由百日咳博德特氏菌释放的无活性毒素形式。
该毒素是以无活性形式由百日咳博德特氏菌释放的。当百日咳毒素B寡聚物结合到细胞膜上时，其A原聚体的S1亚基会被激活，这可能是通过谷胱甘肽和ATP的作用而实现的。 在体外激活百日咳毒素的实验方法是由Kaslow等提供的。
Biochem/physiol Actions
百日咳毒素可催化异三聚体鸟嘌呤核苷酸调节蛋白Gi、Go和Gt的α亚基的ADP-核糖基化。
百日咳毒素可催化异三聚体鸟嘌呤核苷酸调节蛋白Gi、Go和Gt的α亚基的ADP-核糖基化。 这可防止G蛋白异源三聚体与受体的相互作用，从而阻止其偶联和激活。 由于Gα亚基仍处于与GDP结合的非活性状态，因此它们无法使腺苷酸环化酶失活或打开K+通道。
Physical form
aseptically packaged solution in 50% (v/v) glycerol; 50 mM TRIS, pH 7.5; 10 mM glycine; 0.5 M NaCl
Other Notes
Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins; Pertussis toxin-catalyzed ADP-ribosylation of G proteins
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Pertussis toxin-catalyzed ADP-ribosylation of G proteins.
D J Carty
Methods in enzymology, 237, 63-70 (1994-01-01)
Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins.
G Milligan
The Biochemical journal, 255(1), 1-13 (1988-10-01)
Michal Aharonowiz et al.
PloS one, 3(9), e3145-e3145 (2008-09-06)
Multiple sclerosis (MS) is an immune mediated demyelinating disease of the central nervous system (CNS). A potential new therapeutic approach for MS is cell transplantation which may promote remyelination and suppress the inflammatory process. We transplanted human embryonic stem cells
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 324628-10MG | 04055977196719 |