80328
克林霉素 2-磷酸酯
pharmaceutical secondary standard; traceable to USP and PhEur
别名:
Clindamycin 2-dihydrogen phosphate
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关于此项目
经验公式（希尔记法）:
C18H34ClN2O8PS
化学文摘社编号:
分子量:
504.96
EC Number:
246-433-0
UNSPSC Code:
41116000
MDL number:
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. C2269000, traceable to USP 1138008
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
storage temp.
−20°C
SMILES string
CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC([C@H](C)Cl)C2O[C@H](SC)[C@H](OP(O)(O)=O)[C@@H](O)[C@H]2O
InChI
1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12?,13+,14-,15?,16+,18+/m0/s1
InChI key
UFUVLHLTWXBHGZ-MWBQRTRKSA-N
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Biochem/physiol Actions
Spectrum of Activity: Gram positive cocci and taxoplasma. Especially active against anaerobic bacteria.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
Mode of Action: Inhibits protein synthesis in bacterial by binding the 50s ribosomal subunit.
Other Notes
Antibacterial and antiprotozoal antibiotic of the licosamide class.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Lact. - Skin Sens. 1
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Shao-Min Wang et al.
Rapid communications in mass spectrometry : RCM, 23(6), 899-906 (2009-02-18)
A simple high-performance liquid chromatography/electrospray ionization tandem mass spectrometric (HPLC/ESI-MS/MS) method has been developed for the rapid identification of clindamycin phosphate and its degradation products or related impurities in clindamycin phosphate injection. Detection was performed by quadrupole time-of-flight mass spectrometry
Asuka Munehiro et al.
The Journal of dermatological treatment, 23(3), 172-176 (2011-07-16)
Cosmetic moisturisers were applied to one side of the face of 18 male Japanese patients with acne vulgaris who were treated with a topical administration of adapalene and clindamycin phosphate gels. We assessed the alleviating effect of the moisturisers on
L Babayeva et al.
Journal of the European Academy of Dermatology and Venereology : JEADV, 25(3), 328-333 (2010-07-30)
No single effective topical treatment is available for treating all pathogenic factors causing acne vulgaris (AV). Salicylic acid (SA), tretinoin (all-TRA) and clindamycin phosphate (CDP) are known to to be effective agents depending on their comedolytic and anti-inflammatory properties. To
Michael T Jarratt et al.
Journal of drugs in dermatology : JDD, 11(3), 318-326 (2012-03-08)
Topical combination therapy containing a retinoid and an antimicrobial is an effective treatment for acne vulgaris. To evaluate the efficacy and safety of a new topical formulation containing clindamycin phosphate 1.2% and tretinoin 0.025% solubilized in an aqueous-based gel (CT
C Hascicek et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 77(1), 116-121 (2010-11-23)
The aim of this work was to study the clindamycin release kinetics from floating delivery systems consisting of two modules assembled in void configuration, according to the modified release technology platform known as Dome Matrix®. Two modules differently shaped, i.e.
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