InChI key
KNAHARQHSZJURB-UHFFFAOYSA-N
InChI
1S/C7H10N2OS/c1-2-3-5-4-6(10)9-7(11)8-5/h4H,2-3H2,1H3,(H2,8,9,10,11)
SMILES string
CCCC1=CC(=O)NC(=S)N1
Gene Information
human ... DIO1(1733), TPO(7173)
grade
purum
assay
≥98.0% (T)
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Kyla M Walter et al.
General and comparative endocrinology, 272, 20-32 (2018-11-19)
Thyroid hormones (THs) regulate neurodevelopment, thus TH disruption is widely posited as a mechanism of developmental neurotoxicity for diverse environmental chemicals. Zebrafish have been proposed as an alternative model for studying the role of TH in developmental neurotoxicity. To realize
Sarah V Lipchock et al.
The American journal of clinical nutrition, 98(4), 1136-1143 (2013-09-13)
Alleles of the receptor gene TAS2R38 are responsible in part for the variation in bitter taste perception of 6-n-propylthiouracil (PROP) and structurally similar compounds (eg, glucosinolates in cruciferous vegetables). At low concentrations, people with the PAV ("taster" amino acid sequence)
Michael H Powell et al.
Neurotoxicology, 33(5), 1322-1329 (2012-09-15)
Humans and wildlife are exposed to environmental pollutants that have been shown to interfere with the thyroid hormone system and thus may affect brain development. Our goal was to expose pregnant rats to propylthiouracil (PTU) to measure the effects of
Juneo F Silva et al.
Reproduction, fertility, and development, 24(7), 923-931 (2012-09-01)
The objective of this study was to evaluate fetal weight, histomorphometric changes and proliferative activity, apoptosis and angiogenesis of the placenta in rats with hypothyroidism. Thirty-six adult female rats were divided into two groups with 18 animals each: control and
Giuseppe Fede et al.
The Cochrane database of systematic reviews, (6)(6), CD002800-CD002800 (2011-06-17)
Randomised clinical trials have addressed the question whether propylthiouracil has any beneficial effects in patients with alcoholic liver disease. To assess the beneficial and harmful effects of propylthiouracil for patients with alcoholic liver disease. We searched The Cochrane Hepato-Biliary Group
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