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Merck
CN

84606

Sigma-Aldrich

SBFI-AM

≥98.0% (HPCE)

别名:

钠指示剂 SBFI-AM, 钠结合苯并呋喃间苯二甲酸酯-AM

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关于此项目

经验公式（希尔记法）:
C56H58N2O23
化学文摘社编号:
129423-53-6
分子量:
1127.06
MDL编号:
MFCD00082576
UNSPSC代码:
12171500
PubChem化学物质编号:
24888240

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方案

≥98.0% (HPCE)

溶解性

DMSO: soluble
methanol: soluble

荧光

λex 389 nm; λem 580 nm in 0.1 M phosphate pH 7.0 (esterase)

适用性

suitable for fluorescence

储存温度

2-8°C

SMILES字符串

COc1cc2cc(oc2cc1N3CCOCCOCCN(CCOCC3)c4cc5oc(cc5cc4OC)-c6ccc(cc6C(=O)OCOC(C)=O)C(=O)OCOC(C)=O)-c7ccc(cc7C(=O)OCOC(C)=O)C(=O)OCOC(C)=O

InChI

1S/C56H58N2O23/c1-33(59)72-29-76-53(63)37-7-9-41(43(21-37)55(65)78-31-74-35(3)61)49-23-39-25-51(67-5)45(27-47(39)80-49)57-11-15-69-16-12-58(14-18-71-20-19-70-17-13-57)46-28-48-40(26-52(46)68-6)24-50(81-48)42-10-8-38(54(64)77-30-73-34(2)60)22-44(42)56(66)79-32-75-36(4)62/h7-10,21-28H,11-20,29-32H2,1-6H3

InChI key

MWUYLQGOGOLRQS-UHFFFAOYSA-N

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应用

suitable for the detection of Na+

其他说明

Cell permeant deriv. of fluorescent indicator for intracellular sodium

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

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G P Amorino et al.
Cytometry, 21(3), 248-256 (1995-11-01)
Intracellular sodium concentration ([Na+]i) can be measured using SBFI with image analysis or spectrofluorometry. However, SBFI cannot be used with most flow cytometry systems, due to its requirement for dual excitation in the UV range. Recently a new sodium indicator
S Ito et al.
Journal of neuroscience methods, 75(1), 21-27 (1997-07-18)
Palytoxin was found to equilibrate sodium ions (Na+) across the cell membrane much faster than dose gramicidin, which has been frequently used to calibrate the intracellular Na+ concentration ([Na+]in), in cells treated with a Na+-sensitive fluorescent dye, sodium-binding benzofuran isophthalate
A Minta et al.
The Journal of biological chemistry, 264(32), 19449-19457 (1989-11-15)
Fluorescent indicators sensitive to cytosolic concentrations of free Na+ have been synthesized and characterized. They consist of a crown ether, 1,7-diaza-4,10,13-trioxacyclopentadecane, linked via its nitrogens to fluorophores bearing additional liganding centers. In the currently preferred dye, SBFI (short for sodium-binding

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