85660
Staurosporine from Streptomyces sp.
≥95.0% (HPLC)
别名:
Antibiotic AM-2282
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C28H26N4O3
化学文摘社编号:
分子量:
466.53
UNSPSC Code:
12161501
Beilstein/REAXYS Number:
1060573
MDL number:
assay
≥95.0% (HPLC)
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
storage temp.
2-8°C
SMILES string
CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
InChI
1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
InChI key
HKSZLNNOFSGOKW-ZGQXJOJZSA-N
General description
Chemical structure: indol derivative
Biochem/physiol Actions
Potent inhibitor of phospholipid/calcium-dependent protein kinase. Inhibits the upregulation of VEGF expression in tumor cells.
Other Notes
A potent inhibitor of phospholipid / calcium dependent protein kinase; Inhibits the respiratory burst and induces exocytosis in human neutrophils
signalword
Danger
hcodes
Hazard Classifications
Aquatic Chronic 4 - Carc. 1B - Muta. 1B - Repr. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Use and specificity of staurosporine, UCN-01, and calphostin C as protein kinase inhibitors.
T Tamaoki
Methods in enzymology, 201, 340-347 (1991-01-01)
B Dewald et al.
The Biochemical journal, 264(3), 879-884 (1989-12-15)
The protein kinase C inhibitor staurosporine influenced in different ways the functions of human neutrophils. Staurosporine prevented the enhanced protein phosphorylation in phorbol ester- and N-formylmethyionyl-leucylphenylalanine (fMLP)-stimulated cells, and was a powerful inhibitor of the respiratory burst induced by phorbol
T Tamaoki et al.
Biochemical and biophysical research communications, 135(2), 397-402 (1986-03-13)
Staurosporine, microbial alkaloid which has been known to have antifungal activity was found to inhibit markedly phospholipid/Ca++dependent protein kinase (protein kinase C) from rat brain, with an IC50 value of 2.7 nM. However, it had little effect on the binding
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持