85882
链脲菌素
≥98.0% (HPLC)
别名:
链脲佐菌素, 链脲霉素
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关于此项目
经验公式（希尔记法）:
C8H15N3O7
化学文摘社编号:
分子量:
265.22
Beilstein:
2060675
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
≥98.0% (HPLC)
mp
121 °C (dec.) (lit.)
作用机制
DNA synthesis | interferes
储存温度
−20°C
SMILES字符串
CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
InChI
1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
InChI key
ZSJLQEPLLKMAKR-GKHCUFPYSA-N
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一般描述
Chemical structure: aminoglycoside
生化/生理作用
一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物；诱导胰岛素分泌细胞的死亡，产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。
一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物；诱导胰岛素分泌细胞的死亡，产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。 对表达GLUT2葡萄糖转运蛋白的神经内分泌肿瘤细胞系具有细胞毒性。
其他说明
This product has been replaced by S0130-SIGMA | Streptozocin ≥75% α-anomer basis, ≥98% (HPLC), powder
警示用语：
Warning
危险声明
危险分类
Carc. 2 - Flam. Sol. 2 - Muta. 2
储存分类代码
4.1B - Flammable solid hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Bas Brouwers et al.
The Journal of biological chemistry, 288(38), 27200-27207 (2013-08-14)
Streptozotocin (STZ) is widely used as diabetogenic agent in animal models for diabetic nephropathy (DN). However, it is also directly cytotoxic to kidneys, making it difficult to distinguish between DN-related and STZ-induced nephropathy. Therefore, an improved protocol to generate mice
Keith Al-Hasani et al.
Developmental cell, 26(1), 86-100 (2013-07-03)
It was recently demonstrated that embryonic glucagon-producing cells in the pancreas can regenerate and convert into insulin-producing β-like cells through the constitutive/ectopic expression of the Pax4 gene. However, whether α cells in adult mice display the same plasticity is unknown.
Xiaoming Chen et al.
Carbohydrate polymers, 94(1), 378-385 (2013-04-03)
The present study was designed to investigate the effect of OJP1, a polysaccharide isolated from the roots of Ophiopogon japonica, on blood lipid metabolism, antioxidant activity, as well as its protective effect on the liver and kidneys in diabetic rats.
Jayasankar Kosaraju et al.
Neuropharmacology, 72, 291-300 (2013-04-23)
Type 2 diabetes (T2D) is one of the major risk factors associated with Alzheimer's disease (AD). Recent studies have found similarities in molecular mechanisms that underlie the respective degenerative developments in the two diseases. Pharmacological agents, such as dipeptidyl peptidase-4
Streptozocin: a review of its pharmacology, efficacy, and toxicity.
R B Weiss
Cancer treatment reports, 66(3), 427-438 (1982-03-01)
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