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Merck
CN

85882

链脲菌素

≥98.0% (HPLC)

别名:

链脲佐菌素, 链脲霉素

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关于此项目

经验公式(希尔记法):
C8H15N3O7
化学文摘社编号:
分子量:
265.22
EC Number:
242-646-8
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2060675
MDL number:
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InChI key

ZSJLQEPLLKMAKR-GKHCUFPYSA-N

InChI

1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1

SMILES string

CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O

assay

≥98.0% (HPLC)

mp

121 °C (dec.) (lit.)

mode of action

DNA synthesis | interferes

storage temp.

−20°C

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General description

Chemical structure: aminoglycoside

Biochem/physiol Actions

一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物;诱导胰岛素分泌细胞的死亡,产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。
一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物;诱导胰岛素分泌细胞的死亡,产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。 对表达GLUT2葡萄糖转运蛋白的神经内分泌肿瘤细胞系具有细胞毒性。

pictograms

FlameHealth hazard

signalword

Warning

Hazard Classifications

Carc. 2 - Flam. Sol. 2 - Muta. 2

存储类别

4.1B - Flammable solid hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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分析证书(COA)

Lot/Batch Number

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Keith Al-Hasani et al.
Developmental cell, 26(1), 86-100 (2013-07-03)
It was recently demonstrated that embryonic glucagon-producing cells in the pancreas can regenerate and convert into insulin-producing β-like cells through the constitutive/ectopic expression of the Pax4 gene. However, whether α cells in adult mice display the same plasticity is unknown.
Bas Brouwers et al.
The Journal of biological chemistry, 288(38), 27200-27207 (2013-08-14)
Streptozotocin (STZ) is widely used as diabetogenic agent in animal models for diabetic nephropathy (DN). However, it is also directly cytotoxic to kidneys, making it difficult to distinguish between DN-related and STZ-induced nephropathy. Therefore, an improved protocol to generate mice
Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice.
H Kolb
Diabetes/metabolism reviews, 3(3), 751-778 (1987-07-01)
Jayasankar Kosaraju et al.
Neuropharmacology, 72, 291-300 (2013-04-23)
Type 2 diabetes (T2D) is one of the major risk factors associated with Alzheimer's disease (AD). Recent studies have found similarities in molecular mechanisms that underlie the respective degenerative developments in the two diseases. Pharmacological agents, such as dipeptidyl peptidase-4
Xiaoming Chen et al.
Carbohydrate polymers, 94(1), 378-385 (2013-04-03)
The present study was designed to investigate the effect of OJP1, a polysaccharide isolated from the roots of Ophiopogon japonica, on blood lipid metabolism, antioxidant activity, as well as its protective effect on the liver and kidneys in diabetic rats.

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