85882
链脲菌素
≥98.0% (HPLC)
别名:
链脲佐菌素, 链脲霉素
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关于此项目
经验公式（希尔记法）:
C8H15N3O7
化学文摘社编号:
分子量:
265.22
EC Number:
242-646-8
UNSPSC Code:
12352200
PubChem Substance ID:
Beilstein/REAXYS Number:
2060675
MDL number:
InChI key
ZSJLQEPLLKMAKR-GKHCUFPYSA-N
InChI
1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
SMILES string
CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O
assay
≥98.0% (HPLC)
mp
121 °C (dec.) (lit.)
mode of action
DNA synthesis | interferes
storage temp.
−20°C
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General description
Chemical structure: aminoglycoside
Biochem/physiol Actions
一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物；诱导胰岛素分泌细胞的死亡，产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。
一种在胰岛中可作为一氧化氮供体的含N-亚硝基化合物；诱导胰岛素分泌细胞的死亡，产生糖尿病动物模型。可诱导染色体断裂的有效DNA甲基化剂。 对表达GLUT2葡萄糖转运蛋白的神经内分泌肿瘤细胞系具有细胞毒性。
Other Notes
This product has been replaced by S0130-SIGMA | Streptozocin ≥75% α-anomer basis, ≥98% (HPLC), powder
signalword
Warning
hcodes
Hazard Classifications
Carc. 2 - Flam. Sol. 2 - Muta. 2
存储类别
4.1B - Flammable solid hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Bas Brouwers et al.
The Journal of biological chemistry, 288(38), 27200-27207 (2013-08-14)
Streptozotocin (STZ) is widely used as diabetogenic agent in animal models for diabetic nephropathy (DN). However, it is also directly cytotoxic to kidneys, making it difficult to distinguish between DN-related and STZ-induced nephropathy. Therefore, an improved protocol to generate mice
Keith Al-Hasani et al.
Developmental cell, 26(1), 86-100 (2013-07-03)
It was recently demonstrated that embryonic glucagon-producing cells in the pancreas can regenerate and convert into insulin-producing β-like cells through the constitutive/ectopic expression of the Pax4 gene. However, whether α cells in adult mice display the same plasticity is unknown.
Jayasankar Kosaraju et al.
Neuropharmacology, 72, 291-300 (2013-04-23)
Type 2 diabetes (T2D) is one of the major risk factors associated with Alzheimer's disease (AD). Recent studies have found similarities in molecular mechanisms that underlie the respective degenerative developments in the two diseases. Pharmacological agents, such as dipeptidyl peptidase-4
Mouse models of insulin dependent diabetes: low-dose streptozocin-induced diabetes and nonobese diabetic (NOD) mice.
H Kolb
Diabetes/metabolism reviews, 3(3), 751-778 (1987-07-01)
Greg Tesch et al.
Diabetologia, 57(9), 1977-1985 (2014-06-25)
The AGEs and the receptor for AGEs (RAGE) are known contributors to diabetic complications. RAGE also has a physiological role in innate and adaptive immunity and is expressed on immune cells. The aim of this study was to determine whether
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