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Merck
CN

85920

番木鳖碱

≥97.0% (TLC)

别名:

(-)-番木鳖碱

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关于此项目

经验公式(希尔记法):
C21H22N2O2
化学文摘社编号:
分子量:
334.41
EC Number:
200-319-7
UNSPSC Code:
12352200
MDL number:
Beilstein/REAXYS Number:
52979
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assay

≥97.0% (TLC)

mp

284-286 °C (lit.)

SMILES string

[H][C@@]12CC(=O)N3c4ccccc4[C@]56CC[N@H]7CC(=CCO1)[C@]([H])(C[C@@H]57)[C@]2([H])[C@]36[H]

InChI

1S/C21H22N2O2/c24-18-10-16-19-13-9-17-21(6-7-22(17)11-12(13)5-8-25-16)14-3-1-2-4-15(14)23(18)20(19)21/h1-5,13,16-17,19-20H,6-11H2/t13-,16-,17-,19-,20-,21+/m0/s1

InChI key

QMGVPVSNSZLJIA-FVWCLLPLSA-N

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Biochem/physiol Actions

惊厥剂;与 NMDA 受体无关的甘氨酸受体拮抗剂。

pictograms

Skull and crossbonesEnvironment

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Oral - Aquatic Acute 1 - Aquatic Chronic 1

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 2

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Yan Lu et al.
The Journal of clinical investigation, 123(9), 4050-4062 (2013-08-28)
Neuropathic pain is characterized by mechanical allodynia induced by low-threshold myelinated Aβ-fiber activation. The original gate theory of pain proposes that inhibitory interneurons in the lamina II of the spinal dorsal horn (DH) act as "gate control" units for preventing
Susanne Jonsson et al.
Neuropharmacology, 82, 69-75 (2014-04-02)
The ability of drugs of abuse to increase mesolimbic levels of dopamine is a characteristic associated with their rewarding effects. Exactly how these effects are produced by different substances is not as well characterised. Our previous work in rats has
YunXiang Chu et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13796-13804 (2012-10-05)
Depolarization of presynaptic terminals that arises from activation of presynaptic ionotropic receptors, or somatic depolarization, can enhance neurotransmitter release; however, the molecular mechanisms mediating this plasticity are not known. Here we investigate the mechanism of this enhancement at the calyx
Strychnine--a killer from the past.
Igor Makarovsky et al.
The Israel Medical Association journal : IMAJ, 10(2), 142-145 (2008-04-25)
R Thomas Williamson et al.
Organic letters, 14(19), 5098-5101 (2012-09-22)
A relatively unexplored and unexploited means of establishing molecular structure, stereochemistry, and probing vicinal bond angles is through the use of long-range (13)C-(13)C coupling constants. The measurement of these multifunctional, diagnostic (3)J(CC) couplings has not been reported on sample amounts

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