assay
≥96.0% (HPLC)
optical activity
[α]20/D −245±9°, c = 1% in methanol
mp
215-220 °C (dec.), 220-223 °C (lit.)
mode of action
protein synthesis | interferes
storage temp.
2-8°C
SMILES string
Cl.CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)cccc4[C@@]3(C)O
InChI
1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1
InChI key
XMEVHPAGJVLHIG-FMZCEJRJSA-N
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General description
Chemical structure: tetracycline
Biochem/physiol Actions
作用机制：四环素通过细胞膜中的 proin 通道被动扩散，与 30S 核糖体结合，并通过阻止氨酰基 tRNA 进入 mRNA-核糖体复合物上的受体位点来抑制蛋白质合成。它也与细菌的 50S 核糖体亚基结合，改变膜并导致细胞内成分从细菌细胞中泄漏。通过洗涤可以逆转抑制作用，这表明起到抗菌作用的是可逆结合的抗生素，而不是不可逆结合的药物。
耐药性机制：这种作用通过细胞壁通透性的丧失而失活。
抗菌谱：包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。
耐药性机制：这种作用通过细胞壁通透性的丧失而失活。
抗菌谱：包括对革兰氏阳性和革兰氏阴性细菌的广泛抗菌活性。
signalword
Warning
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
涉药品监管产品
此项目有
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