87808
对羟基苯甲酸丁酯
pharmaceutical secondary standard; traceable to USP and PhEur
别名:
4-羟基苯甲酸丁酯
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关于此项目
经验公式（希尔记法）:
C11H14O3
化学文摘社编号:
分子量:
194.23
EC Number:
202-318-7
UNSPSC Code:
41116000
Beilstein/REAXYS Number:
1103741
MDL number:
agency
traceable to Ph. Eur. B1217000, traceable to USP 1084000
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
InChI
1S/C11H14O3/c1-2-3-8-14-11(13)9-4-6-10(12)7-5-9/h4-7,12H,2-3,8H2,1H3
InChI key
QFOHBWFCKVYLES-UHFFFAOYSA-N
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General description
Parabens are suitable as preservative in cosmetics and pharmaceutical industry and also as food additive. Butylparaben is a phenolic preservative. It is slightly soluble in water but is freely soluble in alcohol, acetone and ether.
Application
Butylparaben may be used as reference standard in determination of paraben in beverage samples using dispersive liquid-liquid microextraction (DLLME) combined with gas chromatography-mass spectrometry (GC-MS).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Danger
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
hcodes
Hazard Classifications
ED HH 1 - Eye Dam. 1 - Skin Irrit. 2
法规信息
新产品
此项目有
Alan M Hoberman et al.
Birth defects research. Part B, Developmental and reproductive toxicology, 83(2), 123-133 (2008-04-09)
Parabens are widely used preservatives in cosmetics and pharmaceutical products, and approved as food additives. Parabens have been considered safe for these uses for many years. Recently, adverse effects on male reproductive parameters in rats have been reported when parabens
Quanyun A. Xu, Lawrence A. Trissel
Stability-Indicating HPLC Methods for Drug Analysis, 87-87 (2003)
DLLME combined with GC-MS for the determination of methylparaben, ethylparaben, propylparaben and butylparaben in Beverage Samples.
Han, Yi, et al.
Chromatographia, 73, 351-355 (2010)
Tilak Khanal et al.
Toxicology letters, 213(2), 174-183 (2012-07-21)
Parabens are alkyl esters of p-hydroxybenzoic acid (BA), including methyl paraben (MP), ethyl paraben, propyl paraben (PP), and butyl paraben (BP). In the present study, possible role of metabolism by fecalase in BP-induced cytotoxicity was investigated in HepG2 cell cultures.
Jordan Shaw et al.
Reproductive toxicology (Elmsford, N.Y.), 28(1), 26-31 (2009-06-06)
Parabens, a class of preservatives routinely added to cosmetics, pharmaceuticals, and foods, have estrogenic properties. Given that intrauterine implantation of fertilized ova in inseminated females can be disrupted by minute levels of exogenous estrogens, we assessed the impact of parabens
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