grade
purum
assay
≥96.0% (CH)
optical activity
[α]20/D +283±5°, c = 1% in chloroform
mp
219-222 °C
SMILES string
COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34
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新产品
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Tian Hu Wang et al.
Oncology reports, 28(5), 1681-1686 (2012-09-04)
Multidrug resistance is one of the major causes limiting the efficacy of chemotherapeutic agents to control esophageal cancer. Herein, we investigated that the effect and mechanism of tetrandrine (TET) in the human esophageal squamous carcinoma cisplatin-resistant cell line YES-2/DDP. The
Ping He et al.
Journal of Asian natural products research, 14(6), 564-576 (2012-05-17)
A series of new bisbenzylisoquinoline alkaloids was partially synthesized from tetrandrine and fangchinoline and evaluated for their ability to reverse P-glycoprotein-mediated multidrug resistance (MDR) in cancer cells. All the test compounds increased the intracellular accumulation rate of rhodamine 123 in
Tatsuo Takahashi et al.
Biological & pharmaceutical bulletin, 35(10), 1765-1774 (2012-10-06)
One of the mediators of osteoclast differentiation is receptor activator of nuclear factor κB ligand (RANKL), which is produced by osteoblasts. Binding of RANKL to its receptor, RANK, activates several signaling pathways, including those involving mitogen-activated protein kinases (MAPKs), nuclear