89430
L-甲状腺氨酸 钠盐 五水合物
≥97.0% (sum of enantiomers, HPLC)
别名:
3-[4-(4-羟基-3,5-二碘苯氧基)-3,5-二碘苯基]-L-丙氨酸 钠盐, T4, 左甲状腺素钠
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线性分子式:
HOC6H2I2OC6H2I2CH2CH(NH2)COONa · 5H2O
化学文摘社编号:
分子量:
888.93
EC Number:
200-221-4
UNSPSC Code:
51111800
MDL number:
Beilstein/REAXYS Number:
5721845
assay
≥97.0% (sum of enantiomers, HPLC)
optical activity
[α]20/D +16±1°, c = 2% in ethanol/1 M HCl (4:1)
impurities
~10% water
mp
207-210 (dec.) (lit.)
storage temp.
2-8°C
SMILES string
O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
InChI
1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1
InChI key
JMHCCAYJTTWMCX-QWPJCUCISA-M
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Application
Literatur s. 89405, L-Thyroxine
Biochem/physiol Actions
L-甲状腺素（T4） 和三碘-L-甲状腺原氨酸（T3）是由甲状腺滤泡细胞中的甲状腺球蛋白产生的含碘激素。这些激素对代谢率的刺激和对生长发育的调节似乎是由于它们对 DNA 转录和蛋白质合成的影响。
signalword
Danger
hcodes
Hazard Classifications
STOT RE 1
target_organs
Thyroid,Cardio-vascular system,Kidney
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
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C R González et al.
The Journal of physiology, 587(Pt 14), 3741-3750 (2009-05-28)
Visceral adipose tissue-derived serine protease inhibitor (vaspin) is a recently discovered adipocytokine mainly secreted from visceral adipose tissue, which plays a main role in insulin sensitivity. In this study, we have investigated the regulation of vaspin gene expression in rat
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