89926
(2-Hydroxyethyl-d4)phosphonic acid
PESTANAL®, analytical standard
别名:
2-Hydroxyethane-d4-phosphonic acid, Ethephon-hydroxy-d4
grade
analytical standard
product line
PESTANAL®
assay
≥98.0% (GC)
shelf life
limited shelf life, expiry date on the label
mp
52-60 °C
application(s)
agriculture
format
neat
storage temp.
2-8°C
Quality Level
General description
(2-Hydroxyethyl-d4)phosphonic acid is an isotope-labeled analog of (2-hydroxyethyl)-phosphonic acid, a metabolite of polar pesticide ethephon, wherein dimethylene protons are substituted by deuterium.
Application
(2-Hydroxyethyl-d4)phosphonic acid may be used as a deuterated internal standard to quantify the analyte in foods of plant origin by liquid chromatography-tandem mass spectrometry (LC-MS/MS).
Isotope-labeled compounds are increasingly used in isotope dilution mass spectrometry (IDMS) for the quantitative analysis of pesticides. The major advantage of using this technique is that the isotope-labeled compounds have nearly the same physical properties as their non-labeled counterpart analogs, and thus show identical behavior during the workup and sample preparation process. This helps in overcoming the problems of matrix effects generally encountered in the usual LC-MS/GC-MS analysis potentially resulting in biased results. By spiking the sample before workup with its isotope labeled analog, the loss of analyte that leads to matrix effects can be determined and compensated.
Isotope-labeled compounds are increasingly used in isotope dilution mass spectrometry (IDMS) for the quantitative analysis of pesticides. The major advantage of using this technique is that the isotope-labeled compounds have nearly the same physical properties as their non-labeled counterpart analogs, and thus show identical behavior during the workup and sample preparation process. This helps in overcoming the problems of matrix effects generally encountered in the usual LC-MS/GC-MS analysis potentially resulting in biased results. By spiking the sample before workup with its isotope labeled analog, the loss of analyte that leads to matrix effects can be determined and compensated.
Legal Information
PESTANAL is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1C
存储类别
8B - Non-combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Quick method for the analysis of residues of numerous highly polar pesticides in foods of plant origin involving simultaneous extraction with methanol and LC-MS/MS determination (QuPPe-Method)
Anastassiades M, et al.
Australian Journal of Soil Research, 190, 461226-461226 (2013)
Selective multiresidue determination of highly polar anionic pesticides in plant-based milk, wine and beer using hydrophilic interaction liquid chromatography combined with tandem mass spectrometry
Lopez SH, et al.
Journal of Chromatography A, 190, 461226-461226 (2020)
Simultaneous determination of polar pesticides in human blood serum by liquid chromatography coupled to triple quadrupole mass spectrometer
Lopez-Ruiz R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 190, 113492-113492 (2020)
Quick method for the analysis of residues of numerous highly polar pesticides in foods of plant origin involving simultaneous extraction with methanol and LC-MS/MS determination (QuPPe-Method)
Anastassiades M, et al.
EU Reference Laboratie for Residue of Pesticides (2013)
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