90532
N-Desisopropylpropranolol
analytical standard
别名:
(±)-1-Amino-3-(1-naphthyloxy)-2-propanol, (±)-Norpropranolol, N-Deisopropylpropranolol
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关于此项目
经验公式（希尔记法）:
C13H15NO2
化学文摘社编号:
分子量:
217.26
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
InChI
1S/C13H15NO2/c14-8-11(15)9-16-13-7-3-5-10-4-1-2-6-12(10)13/h1-7,11,15H,8-9,14H2
SMILES string
NCC(O)COC1=CC=CC2=CC=CC=C21
InChI key
ZFMCITCRZXLMDJ-UHFFFAOYSA-N
grade
analytical standard
assay
≥97.5% (HPLC)
shelf life
limited shelf life, expiry date on the label
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤1.0% water (calc. from elemental analysis)
application(s)
pharmaceutical
format
neat
storage temp.
2-8°C
Quality Level
General description
N-Desisopropylpropranolol is one of the active metabolites of propranolol, a widely prescribed β-adrenergic blocking drug for treating arrhythmias, thyrotoxicosis, angina pectoris, and hypertension.
Application
N-Desisopropylpropranolol may be used as an analytical reference standard for the determination of the analyte in various biological samples by chromatography techniques.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Development and validation of a capillary zone electrophoresis method for the determination of propranolol and N-desisopropylpropranolol in human urine
Nevado JJB, et al.
Analytica Chimica Acta, 559(1), 9-14 (2006)
Versatile isocratic high-performance liquid chromatographic assay for propranolol and its basic, neutral and acidic metabolites in biological fluids
Kwong EC and Shen DD
Journal of Chromatography. B, Biomedical Sciences and Applications, 414(65), 365-379 (1987)
An improved HPLC-MS/MS method for simultaneous quantification of propranolol and its two phase I metabolites in plasma of infants with hemangioma and its application to a comparative study of plasma concentrations
He H, et al.
Royal Society of Chemistry Advances, 8(65), 37286-37294 (2018)
Rapid and simultaneous extraction of propranolol, its neutral and basic metabolites from plasma and assay by high-performance liquid chromatography
Harrison PM, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 343(1), 349-358 (1985)
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