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Merck
CN

90779

Poly(maleic anhydride-alt-1-octene), 3-(dimethylamino)-1-propylamine derivative

别名:

PMAL TM-C6

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description

zwitterionic

λ

0.1 % in H2O

UV absorption

λ: 260 nm Amax: ≤0.400, λ: 280 nm Amax: ≤0.150

Application

Use of "Amphipols" for delivering of membrane proteins to lipid bilayers, as activity support of membrane enzymes.

Analysis Note

enzyme traces DNases, RNases, proteases and phosphatases not detectable

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J K Nagy et al.
FEBS letters, 501(2-3), 115-120 (2001-07-27)
Data are presented which suggest that a class of amphiphilic polymers known as 'amphipols' may serve as a vehicle for delivering complex integral membrane proteins into membranes. The integral membrane protein diacylglycerol kinase (DAGK) was maintained in soluble form by
Bonnie M Gorzelle et al.
Journal of the American Chemical Society, 124(39), 11594-11595 (2002-09-26)
Amphipathic polymers ("amphipols") were introduced several years ago (Tribet, C.; Audebert, R.; Popot, J.-L. Proc. Natl. Acad. Sci. U.S.A. 1996, 93, 15047-15050) as an alternative method for solubilizing integral membrane proteins in stable, nativelike conformations. However, direct maintenance of full

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