vapor density
<1 (vs air)
vapor pressure
1 mmHg ( 51 °C)
refractive index
n20/D 1.62 (lit.)
bp
196 °C (lit.)
mp
54-58 °C (lit.)
solubility
water: soluble 81.7 g/L at 20 °C
density
1.62 g/mL at 25 °C (lit.)
SMILES string
OC(=O)C(Cl)(Cl)Cl
InChI
1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
InChI key
YNJBWRMUSHSURL-UHFFFAOYSA-N
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General description
Trichloroacetic acid (TCA) is a chlorinated acetic acid. It is one of the major metabolites of trichloroethylene (TCE).
Application
传统上用于沉淀蛋白质。用于通过定量沉淀测定蛋白质浓度。用作脱钙剂和显微镜样品的固定剂。
Trichloroacetic acid may be used in the following studies:
10% Trichloroacetic acid may be employed for the preparation of radioactive proteins.
- Estimation of phosphorus in various biological samples (serum, urine and stool ash solutions).
- Elimination of acid-soluble and lipid phosphorous during the determination of deoxyribonucleic acid, ribonucleic acid and phosphoproteins in animal tissues.
- Preparation of 2-methyl-4-nitroanilinium trichloroacetate trichloroacetic acid (2M4NATCA) crystals.
10% Trichloroacetic acid may be employed for the preparation of radioactive proteins.
signalword
Danger
hcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A
存储类别
8B - Non-combustible corrosive hazardous materials
wgk
WGK 2
flash_point_f
>235.4 °F - closed cup
flash_point_c
> 113 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
A microcolorimetric method for the determination of inorganic phosphorus.
H H TAUSSKY et al.
The Journal of biological chemistry, 202(2), 675-685 (1953-06-01)
A method for the determination of desoxyribonucleic acid, ribonucleic acid, and phosphoproteins in animal tissues.
G SCHMIDT et al.
The Journal of biological chemistry, 161, 83-89 (1945-01-01)
Solubility of albumin in alcohol after precipitation by trichloroacetic acid: a simplified procedure for separation of albumin.
J R DEBRO et al.
Nature, 178(4541), 1067-1067 (1956-11-10)
S L Herren-Freund et al.
Toxicology and applied pharmacology, 90(2), 183-189 (1987-09-15)
Trichloroethylene (TCE) has previously been shown to be carcinogenic in mouse liver when administered by daily gavage in corn oil. The metabolism of TCE results, in part, in the formation of trichloroacetic acid (TCA) as a major metabolite and dichloroacetic
Hikmat Al-Ahmadie et al.
Cancer discovery, 4(9), 1014-1021 (2014-06-18)
Metastatic solid tumors are almost invariably fatal. Patients with disseminated small-cell cancers have a particularly unfavorable prognosis, with most succumbing to their disease within two years. Here, we report on the genetic and functional analysis of an outlier curative response
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