91403
异戊酰-L -肉碱
analytical standard
别名:
(2 R )-3-羧基- N ， N ， N -三甲基-2-（3-甲基-1-氧代丁氧基）-1-丙胺 内盐, L-肉碱异戊酸酯, iC5-肉碱
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关于此项目
经验公式（希尔记法）:
C12H23NO4
化学文摘社编号:
分子量:
245.32
UNSPSC Code:
41116107
NACRES:
NB.21
Beilstein/REAXYS Number:
5946880
InChI
1S/C12H23NO4/c1-9(2)6-12(16)17-10(7-11(14)15)8-13(3,4)5/h9-10H,6-8H2,1-5H3/t10-/m1/s1
SMILES string
C[N+](C)(C)C[C@H](OC(CC(C)C)=O)CC([O-])=O
InChI key
IGQBPDJNUXPEMT-SNVBAGLBSA-N
grade
analytical standard
assay
≥94.0% (HPLC)
optical activity
[α]/D -23.0±2.0°, c = 0.1 in H2O
shelf life
limited shelf life, expiry date on the label
impurities
≤12% water (calculated from elemental analysis)
application(s)
clinical testing
format
neat
storage temp.
2-8°C
Quality Level
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General description
Isovaleryl-L-carnitine belongs to the acylcarnitines class of compounds. Acyl-L-carnitines are mostly produced from L-carnitine, which plays an important role in fatty acid metabolic pathways. The functions and roles of acyl-L-carnitines in various tissues like brain, heart, and muscle continue to attract much interest, since a number of diseases caused by defects of mitochondrial transport are characterized by specific metabolic dysfunctions and depend on the physiological role of the affected carrier in intermediary metabolism.
Application
Isovaleryl-L-carnitine may be used as an analytical reference standard for the quantification of the analyte in biological samples using chromatography-based techniques.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Separation and identification of underivatized plasma acylcarnitine isomers using liquid chromatography?tandem mass spectrometry for the differential diagnosis of organic acidemias and fatty acid oxidation defects
Peng M, et al.
Journal of Chromatography A, 1319(9), 97-106 (2013)
Ralph Fingerhut et al.
Analytical chemistry, 81(9), 3571-3575 (2009-03-28)
Electrospray ionization-tandem mass spectrometry (ESI-MS/MS) is increasingly used in newborn screening programs. Acylcarnitine profiles from dried blood spots (DBS) are used to detect fatty acid oxidation disorders, carnitine cycle disorders, and organic acidurias. Stored dried blood is also a valuable
Matrix effect?corrected liquid chromatography/tandem mass-spectrometric method for determining acylcarnitines in human urine
Abe K, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 468, 187-194 (2017)
Arif Yurdagul et al.
Cell metabolism, 31(3), 518-533 (2020-02-01)
Continual efferocytic clearance of apoptotic cells (ACs) by macrophages prevents necrosis and promotes injury resolution. How continual efferocytosis is promoted is not clear. Here, we show that the process is optimized by linking the metabolism of engulfed cargo from initial
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