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Merck
CN

92301

单核细胞增多性李斯特菌选择性添加剂 I

suitable for microbiology

别名:

多粘菌素 B 硫酸盐, 单核细胞增生李斯特菌选择性添加剂 I

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选择尺寸

关于此项目

经验公式（希尔记法）:
C55H96N16O13 · 2H2SO4
化学文摘社编号:
1405-20-5
分子量:
1385.61
UNSPSC Code:
41106200
NACRES:
NA.85
EC Number:
215-774-7
MDL number:
MFCD00131991

主要文件

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InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

SMILES string

O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O

sterility

sterile

form

powder

shelf life

limited shelf life, expiry date on the label

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, fungi

application(s)

environmental
food and beverages, microbiology

mode of action

cell membrane | interferes

storage temp.

2-8°C

suitability

Listeria spp.

Quality Level

100

General description

由 ISO 委员会建议用于分离李斯特菌的选择性添加剂。
Chemical structure: peptide

Application

for the isolation of Listeria species

Biochem/physiol Actions

作用机制：多粘菌素B硫酸盐结合到细菌脂多糖的脂质部分†上，通过诱导足够大的孔来破坏细胞质膜，使核苷酸泄漏到细菌的细胞壁中。 这可破环细胞质膜的半透性。

抗菌谱：对大多数革兰氏阴性杆菌，包括 大肠杆菌 ，真菌和革兰氏阳性菌都有杀菌作用。

Other Notes

（每瓶，足够用于 500mL 培养基）
硫酸多粘菌素 B 38350IU

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCC1960
BCCB2658
BCBV0595
BCBT4252
BCBT0349

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Kensuke Nakamura et al.
The American journal of emergency medicine, 31(5), 893-893 (2013-02-13)
Septic patients often have low cardiac output. Some of them present severe cardiac dysfunction such as septic cardiomyopathy. However, no well-known and effective treatment for septic cardiomyopathy exists. The effect of endotoxin adsorption by polymyxin B–immobilized fiber column–direct hemoperfusion (PMX-DHP)
A Bonura et al.
Allergy, 68(3), 297-303 (2013-01-22)
The major allergens in Parietaria pollen, Par j 1 and Par j 2, have been identified as lipid transfer proteins. The family of the Par j 1 allergens is composed of two isoforms, which differ by the presence of a
Lee Sun New et al.
Analytical and bioanalytical chemistry, 405(4), 1407-1415 (2012-11-28)
With increasing multidrug resistance coupled to a poor development pipeline, clinicians are exploring antimicrobial combinations to improve treatment outcomes. In vitro hollow-fiber infection model (HFIM) is employed to simulate human in vivo drug clearance and investigate pharmacodynamic synergism of antibiotics.
The novel polymyxin derivative NAB739 is remarkably less cytotoxic than polymyxin B and colistin to human kidney proximal tubular cells.
Martti Vaara et al.
International journal of antimicrobial agents, 41(3), 292-293 (2012-11-28)
Conjugated polymer-coated bacteria for multimodal intracellular and extracellular anticancer activity.
Chunlei Zhu et al.
Advanced materials (Deerfield Beach, Fla.), 25(8), 1203-1208 (2013-01-03)
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实验方案

李斯特菌：不可不防

近年来，李斯特菌病被定为重大的公共健康问题。这种病的主要感染对象是老年人、孕妇、新生儿和免疫功能低下者。

Understanding Listeria: Guide to Listeria Monocytogenes and Its Impact on Food Safety

Ensure food safety with our robust Listeria monocytogenes testing methods, including biochemical tests, chromogenic media, and rapid detection methods.

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