940097
SPho Pd G2
solid
别名:
SPhos-Pd-G2, 氯（2-二环己基膦-2′,6′-二甲氧基-1,1′-联苯）[2-（2′-氨基-1,1′-联苯）] 钯(II), 第二代 SPhos 预催化剂
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经验公式（希尔记法）:
C38H45ClNO2PPd
化学文摘社编号:
分子量:
720.62
UNSPSC Code:
12352100
MDL number:
NACRES:
NA.21
产品名称
SPho Pd G2,
InChI
1S/C26H35O2P.C12H10N.ClH.Pd/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;;/h9-11,16-21H,3-8,12-15H2,1-2H3;1-6,8-9H,13H2;1H;/q;;;+1/p-1
SMILES string
COC1=CC=CC(OC)=C1C2=C(P(C3CCCCC3)C4CCCCC4)C=CC=C2.NC5=C(C6=C([Pd]Cl)C=CC=C6)C=CC=C5
InChI key
NOMWEFBAPVZIIP-UHFFFAOYSA-M
Quality Level
product line
ChemBeads
form
solid
composition
loading, 4-6 wt. %
greener alternative product characteristics
Waste Prevention
Catalysis
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
mp
218 °C (dec.)
greener alternative category
General description
The ChemBeads product of SPhos Pd G2, a second generation (G2) precatalyst in which phenethylamine based backbone of the (G1) complex is substituted with a biphenyl-based ligand. This improvement on the previous generation allows creating the active palladium species at room temperature with weak phosphate or carbonate bases. The catalyst proves remarkably adept at achieving a variety of Suzuki-Miyaura couplings among other cross-coupling reactions.s. Loaded on glass beads for use in high-throughput expermentation (HTE).
We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Greener Chemistry. ChemBeads are advanced solid-coated beads for high-throughput experimentation in various chemical applications. They enable precise dispensing of solid reagents, allowing researchers to conduct reactions with minimal material use, thus supporting waste prevention and catalysis principles while ensuring accuracy and reproducibility. This technology enhances efficiency and streamlines experimental processes in chemistry. Click here for more information.
Application
Application in Suzuki-Miyaura coupling:
Self-arylation of 1-alkyl-3-bromo-2-phenyl-2,1-borazaronaphthalenes to form 2,1-borazaronaphthols.
Suzuki–Miyaura coupling of β-borylated porphyrins with 2-iodoaniline.
Suzuki-Miyaura cross-coupling of unprotected, nitrogen-rich heterocycles.
The cyanomethylation of (hetero)aryl halides or triflates as a tandem reaction for the synthesis of DNA-encoded libraries.[4] (37677078)
ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.
For general uses, product is also available in powdered form 753009
Self-arylation of 1-alkyl-3-bromo-2-phenyl-2,1-borazaronaphthalenes to form 2,1-borazaronaphthols.
Suzuki–Miyaura coupling of β-borylated porphyrins with 2-iodoaniline.
Suzuki-Miyaura cross-coupling of unprotected, nitrogen-rich heterocycles.
The cyanomethylation of (hetero)aryl halides or triflates as a tandem reaction for the synthesis of DNA-encoded libraries.[4] (37677078)
ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.
For general uses, product is also available in powdered form 753009
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Bryan T Ingoglia et al.
Tetrahedron, 75(32), 4199-4211 (2020-01-04)
Over the past three decades, Pd-catalyzed cross-coupling reactions have become a mainstay of organic synthesis. In particular, catalysts derived from biaryl monophosphines have shown wide utility in forming C-N bonds under mild reaction conditions. This work summarizes a variety of
Ana L Aguirre et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 27(51), 12981-12986 (2021-07-08)
High-throughput experimentation (HTE) methods are central to modern medicinal chemistry. While many HTE approaches to C-N and Csp2 -Csp2 bonds are available, options for Csp2 -Csp3 bonds are limited. We report here how the adaptation of nickel-catalyzed cross-electrophile coupling of
Noah P Tu et al.
Angewandte Chemie (International ed. in English), 58(24), 7987-7991 (2019-03-21)
Technologies that enable rapid screening of diverse reaction conditions are of critical importance to methodology development and reaction optimization, especially when molecules of high complexity and scarcity are involved. The lack of a general solid dispensing method for chemical reagents
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