96861
Piericidin A from Streptomyces mobaraensis
≥90.0% (HPLC), liquid, green-yellow
别名:
Shaoguanmycin B
方案
≥90.0% (HPLC)
表单
liquid
缺失
<10% loss on drying
颜色
green-yellow
抗生素抗菌谱
fungi
作用机制
enzyme | inhibits
运输
wet ice
储存温度
2-8°C
SMILES字符串
COc1nc(C\C=C(/C)C\C=C\C(C)=C\[C@@H](C)[C@@H](O)\C(C)=C\C)c(C)c(O)c1OC
InChI
1S/C25H37NO4/c1-9-18(4)22(27)19(5)15-17(3)12-10-11-16(2)13-14-21-20(6)23(28)24(29-7)25(26-21)30-8/h9-10,12-13,15,19,22,27H,11,14H2,1-8H3,(H,26,28)/b12-10+,16-13+,17-15+,18-9+/t19-,22+/m1/s1
InChI key
BBLGCDSLCDDALX-LKGBESRRSA-N
其他说明
Neurotoxin for the respiratory chain
警示用语：
Danger
危险分类
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
储存分类代码
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
R R Ramsay et al.
The Biochemical journal, 273(Pt 2), 481-484 (1991-01-15)
1-Methyl-4-phenylpyridinium (MPP+), the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), interrupts mitochondrial electron transfer at the NADH dehydrogenase-ubiquinone junction, as do the respiratory chain inhibitors rotenone, piericidin A and barbiturates. Proof that these classical respiratory chain inhibitors and MPP+ react at
Screening of interleukin-2 production inhibitor with mouse thymoma EL4 cells.
Soon Cheol Ahn et al.
The Journal of antibiotics, 55(11), 1013-1015 (2003-01-28)
T P Singer et al.
Biochimica et biophysica acta, 1187(2), 198-202 (1994-08-30)
This article summarizes recent studies in the authors' and other laboratories of selective inhibitors acting at the 'rotenone' site and at the Q binding site in the NADH-Q oxidoreductase segment of the respiratory chain. A wide array of inhibitors act
Martin J Schnermann et al.
Journal of the American Chemical Society, 128(36), 11799-11807 (2006-09-07)
Full details of the total synthesis of piericidin A1 and B1 and its extension to the preparation of a series of key analogues are described including ent-piericidin A1 (ent-1), 4'-deshydroxypiericidin A1 (58), 5'-desmethylpiericidin A1 (73), 4'-deshydroxy-5'-desmethylpiericidin A1 (75), and the
Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species.
Romana Fato et al.
Biochimica et biophysica acta, 1787(5), 384-392 (2008-12-09)
We have investigated the production of reactive oxygen species (ROS) by Complex I in isolated open bovine heart submitochondrial membrane fragments during forward electron transfer in presence of NADH, by means of the probe 2',7'-Dichlorodihydrofluorescein diacetate. ROS production by Complex
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