96861
Piericidin A from Streptomyces mobaraensis
≥90.0% (HPLC), liquid, green-yellow
别名:
Shaoguanmycin B
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关于此项目
经验公式（希尔记法）:
C25H37NO4
化学文摘社编号:
分子量:
415.57
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C25H37NO4/c1-9-18(4)22(27)19(5)15-17(3)12-10-11-16(2)13-14-21-20(6)23(28)24(29-7)25(26-21)30-8/h9-10,12-13,15,19,22,27H,11,14H2,1-8H3,(H,26,28)/b12-10+,16-13+,17-15+,18-9+/t19-,22+/m1/s1
SMILES string
COc1nc(C\C=C(/C)C\C=C\C(C)=C\[C@@H](C)[C@@H](O)\C(C)=C\C)c(C)c(O)c1OC
InChI key
BBLGCDSLCDDALX-LKGBESRRSA-N
assay
≥90.0% (HPLC)
form
liquid
loss
<10% loss on drying
color
green-yellow
antibiotic activity spectrum
fungi
mode of action
enzyme | inhibits
shipped in
wet ice
storage temp.
2-8°C
Other Notes
Neurotoxin for the respiratory chain
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
R R Ramsay et al.
The Biochemical journal, 273(Pt 2), 481-484 (1991-01-15)
1-Methyl-4-phenylpyridinium (MPP+), the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), interrupts mitochondrial electron transfer at the NADH dehydrogenase-ubiquinone junction, as do the respiratory chain inhibitors rotenone, piericidin A and barbiturates. Proof that these classical respiratory chain inhibitors and MPP+ react at
Screening of interleukin-2 production inhibitor with mouse thymoma EL4 cells.
Soon Cheol Ahn et al.
The Journal of antibiotics, 55(11), 1013-1015 (2003-01-28)
Martin J Schnermann et al.
Journal of the American Chemical Society, 128(36), 11799-11807 (2006-09-07)
Full details of the total synthesis of piericidin A1 and B1 and its extension to the preparation of a series of key analogues are described including ent-piericidin A1 (ent-1), 4'-deshydroxypiericidin A1 (58), 5'-desmethylpiericidin A1 (73), 4'-deshydroxy-5'-desmethylpiericidin A1 (75), and the
Martin J Schnermann et al.
Journal of the American Chemical Society, 127(45), 15704-15705 (2005-11-10)
The first total syntheses of piericidin A1 and B1 are disclosed and unambiguously establish the relative and absolute stereochemistry of the natural products by an approach that will facilitate the synthesis of a series of analogues. Central to the approach
Ji-Hwan Hwang et al.
Journal of cellular physiology, 215(1), 243-250 (2007-10-18)
Glucose deprivation, a pathophysiological cell condition, causes up-regulation of GRP78 and induction of etoposide resistance in human cancer cells. The induction of drug resistance can be partly explained by the fact that GRP78 can block activation of caspase-7 induced by
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