H8760
氢氟噻嗪
analytical standard, ~97%
别名:
3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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关于此项目
经验公式（希尔记法）:
C8H8F3N3O4S2
化学文摘社编号:
分子量:
331.29
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
205-173-8
MDL number:
grade
analytical standard
assay
~97%
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
forensics and toxicology
pharmaceutical (small molecule)
format
neat
SMILES string
O=S1(C2=CC(S(=O)(N)=O)=C(C(F)(F)F)C=C2NCN1)=O
InChI
1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
InChI key
DMDGGSIALPNSEE-UHFFFAOYSA-N
Gene Information
human ... SLC12A3(6559)
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General description
Hydroflumethiazide is a thiazide diuretic drug, which acts like a potent antihypertensive agent. It is used in combination with spironolactone to minimize the excessive loss of potassium in hypokalemic patients who require diuretic therapy.
Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Hydroflumethiazide may be used as a reference standard in the determination of hydroflumethiazide in urine samples using micellar liquid chromatography coupled with fluorimetry detector (MLC).
Hydroflumethiazide may be used as a reference standard in the determination of hydroflumethiazide in urine samples using micellar liquid chromatography coupled with fluorimetry detector (MLC).
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
B Maharaj et al.
Journal of human hypertension, 7(5), 447-450 (1993-10-01)
This randomised, double-blind study compared the efficacy and safety of a fixed combination of hydroflumethiazide 50 mg and reserpine 0.125 mg (H-R) and chlortalidone 12.5 mg and atenolol 50 mg (C-A) in adult black patients with mild to moderate hypertension
S Suzuki et al.
No to shinkei = Brain and nerve, 38(2), 155-161 (1986-02-01)
The susceptibility to cerebral ischemia was studied in stroke-resistant spontaneously hypertensive rats (SHRSR) treated by a long-term antihypertensive treatment, and compared with untreated SHRSR and Wistar rats (WR). Male SHRSR, aged 8 weeks, were divided into two groups and a
X Liu et al.
Biopharmaceutics & drug disposition, 18(2), 93-101 (1997-03-01)
The objective of this work was to develop a simple residual method to estimate the rate constant for actual or apparent zero-order absorption into a one-compartment model. The method is based on the fact that, in theory, a plot of
Chromatographic determination of diuretics in urine samples using hybrid micellar mobile phases with fluorimetric detection.
Carda-Broch.S, et al.
Analytica Chimica Acta, 375(1-2), 143-154 (1998)
G O Yonga et al.
East African medical journal, 70(11), 696-700 (1993-11-01)
In a prospective single-blind comparative trial, sixty newly diagnosed mild to moderate hypertensives were randomly assigned to either propranolol or hydroflumethiazide monotherapy. Baseline fasting serum glucose lipid profiles, serum uric acid and potassium levels, were determined at the beginning of
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