H8760
氢氟噻嗪
analytical standard, ~97%
别名:
3,4-Dihydro-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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关于此项目
经验公式（希尔记法）:
C8H8F3N3O4S2
化学文摘社编号:
分子量:
331.29
EC 号:
MDL编号:
UNSPSC代码:
41116107
PubChem化学物质编号:
等级
analytical standard
方案
~97%
技术
HPLC: suitable
gas chromatography (GC): suitable
应用
forensics and toxicology
pharmaceutical (small molecule)
包装形式
neat
SMILES字符串
O=S1(C2=CC(S(=O)(N)=O)=C(C(F)(F)F)C=C2NCN1)=O
InChI
1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
InChI key
DMDGGSIALPNSEE-UHFFFAOYSA-N
基因信息
human ... SLC12A3(6559)
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一般描述
Hydroflumethiazide is a thiazide diuretic drug, which acts like a potent antihypertensive agent. It is used in combination with spironolactone to minimize the excessive loss of potassium in hypokalemic patients who require diuretic therapy.
应用
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
Hydroflumethiazide may be used as a reference standard in the determination of hydroflumethiazide in urine samples using micellar liquid chromatography coupled with fluorimetry detector (MLC).
Hydroflumethiazide may be used as a reference standard in the determination of hydroflumethiazide in urine samples using micellar liquid chromatography coupled with fluorimetry detector (MLC).
警示用语：
Danger
危险声明
危险分类
Resp. Sens. 1 - Skin Sens. 1
储存分类代码
13 - Non Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
M Hatch et al.
Clinical science (London, England : 1979), 86(3), 353-357 (1994-03-01)
1. The purpose of the present study was to examine the effects of various diuretics on intestinal oxalate transport. Transmural oxalate fluxes were measured across isolated, short-circuited tissue segments removed from rabbits and placed in Ussing chambers. 2. The net
O Brørs et al.
Research communications in chemical pathology and pharmacology, 58(2), 277-280 (1987-11-01)
The effect of potassium depletion and a thiazide diuretic on glucose metabolism was investigated in male rats. Potassium depletion was induced by potassium-deficient diet and ion-exchange resin by stomach tube for 5 days. Plasma and muscle potassium was reduced by
W P Leary et al.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 70(2), 95-98 (1986-07-19)
In a double-blind placebo-controlled investigation, 14 healthy adult male volunteers were studied to assess and compare the urinary effects of acute single doses of two antihypertensive formulations containing: hydroflumethiazide 50 mg, Rauwolfia serpentina 50 mg and potassium chloride 625 mg
S I Abdel-Rahman et al.
Acta pharmaceutica Hungarica, 60(2-3), 69-75 (1990-05-01)
The interaction of three structurally related benzothiadiazine diuretics, viz., hydroflumethiazide, bendrofluazide and cyclopenthiazide wit beta-cyclodextrin was investigated. The study aimed at enhancing the solubility of these poorly soluble drugs via inclusion complexation with beta-cyclodextrin, Solubility measurements revealed that complexes were
O Schmitz et al.
Diabetes care, 9(6), 631-636 (1986-11-01)
The influence of short-term thiazide treatment on peripheral tissue and liver sensitivity to insulin in insulin-dependent diabetes mellitus was determined by the euglycemic insulin clamp technique. A sequential three-step hyperinsulinemic clamp was performed in six insulin-dependent diabetics before and after
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