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Y0000702

Metolazone for system suitability

Name: Metolazone for system suitability
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

别名:

Metolazone, 7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₆ClN₃O₃S

化学文摘社编号:

17560-51-9

分子量:

365.83

NACRES:

NA.24

PubChem Substance ID:

329831105

UNSPSC Code:

41116107

MDL number:

MFCD00069304

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属性

grade

pharmaceutical primary standard

API family

metolazone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O

InChI

1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)

InChI key

AQCHWTWZEMGIFD-UHFFFAOYSA-N

Gene Information

human ... SLC12A3(6559)

说明

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Metolazone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Inhibitor of thiazide-sensitive Na⁺-Cl^- cotransporter; antihypertensive; moderate "loop" diuretic.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Metolazone and its role in edema management.

Domenic A Sica

Congestive heart failure (Greenwich, Conn.), 9(2), 100-105 (2003-04-03)

Metolazone is commonly administered in conjunction with a loop diuretic to manage volume overload in patients otherwise resistant to loop diuretic therapy alone. Metolazone is a thiazide-type diuretic that is characterized by slow and sometimes erratic absorption when administered as

Pre-dosing metolazone with loop diuretic combination regimens.

Raymond A Lorenz et al.

Nephrology nursing journal : journal of the American Nephrology Nurses' Association, 33(1), 78-79 (2006-03-17)

Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.

Monimoy Banerjee et al.

Biochemical pharmacology, 92(2), 389-402 (2014-09-03)

Human pregnane X receptor (hPXR) regulates the expression of drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) and drug transporters such as multidrug-resistance protein 1 (MDR1). PXR can be modulated by small molecules, including Federal Drug Administration (FDA)-approved drugs, thus altering drug

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货号	GTIN
Y0000702	04061837583537