Name: (–)-PSI Reagent
Brand: SIAL

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About This Item

经验公式（希尔记法）:

C₁₆H₁₆F₅OPS₃

CAS Number:

2245335-70-8

分子量:

446.46

MDL编号:

MFCD32068365

UNSPSC代码:

12352101

NACRES:

NA.22

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方案

95%

表单

powder or crystals

mp

103-107 °C

SMILES字符串

Fc1c(c(c(c(c1F)F)S[P]2(=S)S[C@@]3([C@@H](O2)C[C@@H](CC3)C(=C)C)C)F)F

InChI

1S/C16H16F5OPS3/c1-7(2)8-4-5-16(3)9(6-8)22-23(24,26-16)25-15-13(20)11(18)10(17)12(19)14(15)21/h8-9H,1,4-6H2,2-3H3/t8-,9+,16+,23?/m1/s1

InChI key

YPYCUYPOHPPYAS-QSHUGKRNSA-N

应用

Air- and moisture-tolerant, this (-)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (+)-PSI Reagent, is also available (cat# ALD00604).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).

Learn more about PI and PSI reagents