B3916
波尔定碱
analytical standard
别名:
2,9-二羟基-1,10-二甲氧基阿朴啡
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关于此项目
经验公式（希尔记法）:
C19H21NO4
化学文摘社编号:
分子量:
327.37
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
207-509-9
Beilstein/REAXYS Number:
94036
MDL number:
InChI key
LZJRNLRASBVRRX-ZDUSSCGKSA-N
InChI
1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1
SMILES string
COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c-2c34)cc1O
biological source
plant (Peumus boldus molina)
grade
analytical standard
assay
≥98% (TLC)
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
impurities
≤1% isopropanol
mp
157-164 °C
Quality Level
application(s)
food and beverages
forensics and toxicology
veterinary
format
neat
storage temp.
room temp
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General description
Boldine is an aporphine alkaloid isolated from Boldo tree and other plant species. It is a free radical scavenger with anti-inflammatory activity while exhibiting other pharmacological effects such as antidiabetic, antiplatelet aggregation, antipyretic, antinociceptive, antiatherogenic, hepatoprotective and endothelium-protective activity.
Application
Boldine may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical preparations using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
C I Cámara et al.
Talanta, 83(2), 623-630 (2010-11-30)
The quantitative determination of boldine alkaloid in boldo leaf extracts by employing cyclic voltammetry, at a liquid/liquid interface as well as the validation of this methodology against the reference method, high performance liquid chromatography (HPLC), are reported in the present
Fiorenza Rancan et al.
Journal of photochemistry and photobiology. B, Biology, 68(2-3), 133-139 (2002-12-07)
Natural substances extracted from lichens and boldo tree were tested in vivo and in vitro as possible UV-light filters. The protection factors were compared with that found for the references: Nivea sun Spray LSF 5, octylmethoxycinnamate (OMC) and 4-tert.-butyl-4'-methoxy dibenzoylmethane
N Santanam et al.
Atherosclerosis, 173(2), 203-210 (2004-04-06)
A corollary to the oxidation hypothesis of atherosclerosis is that the consumption of antioxidants is beneficial. However, the literature is divided in support of this conclusion. In this study, Boldine, an alkaloid of Peumus boldus and reduced form of RU486
Development of an HPLC fluorescence method for determination of boldine in plasma, bile and urine of rats and identification of its major metabolites by LC?MS/MS
Hroch M, et al.
Journal of Chromatography A, 936, 48-56 (2013)
Franz A Thomet et al.
Natural product communications, 5(10), 1587-1590 (2010-12-03)
Two new boldine derivatives: the 3-thiocarbamateboldine (3) and the 2,9-O,O-diacetyl-3-thiocarbamateboldine (4) have been synthesized and their cytotoxicity evaluated.
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