B3916
波尔定碱
analytical standard
别名:
2,9-二羟基-1,10-二甲氧基阿朴啡
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关于此项目
经验公式（希尔记法）:
C19H21NO4
化学文摘社编号:
分子量:
327.37
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
EC Number:
207-509-9
Beilstein/REAXYS Number:
94036
MDL number:
产品名称
波尔定碱, analytical standard
InChI key
LZJRNLRASBVRRX-ZDUSSCGKSA-N
InChI
1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1
SMILES string
COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c-2c34)cc1O
biological source
plant (Peumus boldus molina)
grade
analytical standard
assay
≥98% (TLC)
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
impurities
≤1% isopropanol
mp
157-164 °C
solubility
ethanol: 50 mg/mL
application(s)
food and beverages
forensics and toxicology
veterinary
format
neat
storage temp.
room temp
Quality Level
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Application
Boldine may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical preparations using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
General description
Boldine is an aporphine alkaloid isolated from Boldo tree and other plant species. It is a free radical scavenger with anti-inflammatory activity while exhibiting other pharmacological effects such as antidiabetic, antiplatelet aggregation, antipyretic, antinociceptive, antiatherogenic, hepatoprotective and endothelium-protective activity.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
涉药品监管产品
此项目有
Franz A Thomet et al.
Molecules (Basel, Switzerland), 16(3), 2253-2258 (2011-03-09)
2,9-Dimethoxymethylboldine (2), 2,9-dimethoxymethyl-3-bromoboldine (3) and 2,9-dimethoxymethyl-3-diphenylphosphinylboldine (4) have been synthesized in an effort to find compounds with potential pharmacological applications. The cytotoxic activities of the natural precursor 1 and these three derivatives have been measured as IC₅₀ inhibitory growth. The
Advances in development of dopaminergic aporphinoids.
Ao Zhang et al.
Journal of medicinal chemistry, 50(2), 171-181 (2007-01-19)
HPLC analysis of boldine in pharmaceuticals
Orsi D.D, et al.
Chromatographia, 44(11-12), 610-622 (1997)
Eduardo L Konrath et al.
Neurotoxicology, 29(6), 1136-1140 (2008-07-02)
Boldine is one of the most potent natural antioxidants and displays some important pharmacological activities, such as cytoprotective and anti-inflammatory activities, which may arise from its free radical scavenging properties. Given that the pathogenesis of brain ischemia/reperfusion has been associated
Mat Ropi Mukhtar et al.
Molecules (Basel, Switzerland), 14(3), 1227-1233 (2009-03-28)
The stem bark of Phoebe grandis afforded one new oxoproaporphine; (-)-grandine A (1), along with six known isoquinoline alkaloids: (-)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and
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