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Merck
CN

C1484

7-二乙氨基-3-(4-马来酰亚胺苯基)-4-甲基香豆素

≥95% purity (HPLC), solid

别名:

1 H -吡咯-2,5-二酮,1-(4-(7-(二乙氨基)-4-甲基-2-氧代-2 H -1-苯并吡喃-3-基)苯基)-, CPM

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关于此项目

经验公式(希尔记法):
C24H22N2O4
化学文摘社编号:
分子量:
402.44
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
MDL number:
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产品名称

7-二乙氨基-3-(4-马来酰亚胺苯基)-4-甲基香豆素, ≥95% (HPLC), solid

SMILES string

CCN(CC)c1ccc2C(C)=C(C(=O)Oc2c1)c3ccc(cc3)N4C(=O)C=CC4=O

InChI

1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3

InChI key

YGIABALXNBVHBX-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

technique(s)

titration: suitable

color

yellow

solubility

DMSO: soluble
methanol: soluble

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

−20°C

Quality Level

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Application

7-二乙氨基-3-(4-马来酸亚胺基苯基)-4-甲基香豆素用于:
  • 作为无毒替代品,与抗体结合(93)
  • 在人 N--肉豆蔻酰基转移酶测定中,辅助荧光检测辅酶A(CoA-SH)(94)
  • 重组蛋白热稳定性转变测定(95)

Biochem/physiol Actions

用于监测硫醇的释放,定量微孔板反应中的硫醇,并通过核仁蛋白染色区分增殖的癌细胞。

General description

7-二乙氨基-3-(4-马来酸亚胺基苯基)-4-甲基香豆素(CPM)是具有高度荧光特性,含巯基(-SH)的香豆素衍生物。激发和发射波长分别为355 nm和460 nm。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Targeting Acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases
Cao JS, et al.
The Journal of biological chemistry, 286(48), 41838-41851 (2011)
Dorien Goubert et al.
Pain practice : the official journal of World Institute of Pain, 15(8), 765-777 (2014-11-13)
Pain facilitation as well as pain inhibition might be present in chronic pain patients. A decreased efficacy of pain inhibition can be measured by conditioned pain modulation (CPM). The use of the CPM paradigm in scientific research has boosted over
Evys Collazo et al.
Analytical biochemistry, 342(1), 86-92 (2005-06-17)
Histone methyltransferases (HMTs) catalyze the S-adenosylmethionine (AdoMet)-dependent methylation of lysines and arginines in the nucleosomal core histones H3 and H4 and the linker histone H1b. Methylation of these residues regulates either transcriptional activation or silencing, depending on the residue modified
S Lutsenko et al.
Biochemistry, 32(26), 6737-6743 (1993-07-06)
The role of the Na,K-ATPase beta-subunit in stabilization of ion-binding sites has been investigated. Treatment of the purified renal Na,K-ATPase with 0.25 M DTT at 40 degrees C for 1 h resulted in 50% loss of Rb occlusion, which correlates
Tamara N Tsalkova et al.
Biochemistry, 46(1), 106-119 (2007-01-03)
Design of a partially cysteine-depleted C98S/C239S/C377S/C468A cytochrome P450 3A4 mutant designated CYP3A4(C58,C64) allowed site-directed incorporation of thiol-reactive fluorescent probes into alpha-helix A. The site of modification was identified as Cys-64 with the help of CYP3A4(C58) and CYP3A4(C64), each bearing only

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