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C1484

7-二乙氨基-3-（4-马来酰亚胺苯基）-4-甲基香豆素

Name: 7-二乙氨基-3-（4-马来酰亚胺苯基）-4-甲基香豆素
Brand: SIAL

≥95% purity (HPLC), solid

别名:

1 H -吡咯-2,5-二酮，1-（4-（7-（二乙氨基）-4-甲基-2-氧代-2 H -1-苯并吡喃-3-基）苯基）-, CPM

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关于此项目

经验公式（希尔记法）:

C₂₄H₂₂N₂O₄

化学文摘社编号:

76877-33-3

分子量:

402.44

UNSPSC Code:

12171500

PubChem Substance ID:

24892413

NACRES:

NA.47

MDL number:

MFCD00077334

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产品名称

7-二乙氨基-3-（4-马来酰亚胺苯基）-4-甲基香豆素, ≥95% (HPLC), solid

Quality Level

100

assay

≥95% (HPLC)

form

solid

technique(s)

titration: suitable

color

yellow

solubility

DMSO: soluble, methanol: soluble

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

−20°C

SMILES string

CCN(CC)c1ccc2C(C)=C(C(=O)Oc2c1)c3ccc(cc3)N4C(=O)C=CC4=O

InChI

1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3

InChI key

YGIABALXNBVHBX-UHFFFAOYSA-N

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General description

7-二乙氨基-3-（4-马来酸亚胺基苯基）-4-甲基香豆素（CPM）是具有高度荧光特性，含巯基（-SH）的香豆素衍生物。激发和发射波长分别为355 nm和460 nm。

Application

7-二乙氨基-3-（4-马来酸亚胺基苯基）-4-甲基香豆素用于：

作为无毒替代品，与抗体结合（93）
在人 N--肉豆蔻酰基转移酶测定中，辅助荧光检测辅酶A（CoA-SH）（94）
重组蛋白热稳定性转变测定（95）

Biochem/physiol Actions

用于监测硫醇的释放，定量微孔板反应中的硫醇，并通过核仁蛋白染色区分增殖的癌细胞。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cao JS, et al.

The Journal of biological chemistry, 286(48), 41838-41851 (2011)

Somatosensory assessment and conditioned pain modulation in temporomandibular disorders pain patients.

Simple Futarmal Kothari et al.

Pain, 156(12), 2545-2555 (2015-08-27)

The pathophysiology and underlying pain mechanisms of temporomandibular disorders (TMD) are poorly understood. The aims were to assess somatosensory function at the temporomandibular joints (TMJs) and to examine whether conditioned pain modulation (CPM) differs between TMD pain patients (n =

An essential role for the extracellular domain of the Na,K-ATPase beta-subunit in cation occlusion.

S Lutsenko et al.

Biochemistry, 32(26), 6737-6743 (1993-07-06)

The role of the Na,K-ATPase beta-subunit in stabilization of ion-binding sites has been investigated. Treatment of the purified renal Na,K-ATPase with 0.25 M DTT at 40 degrees C for 1 h resulted in 50% loss of Rb occlusion, which correlates

Effect of Pain Induction or Pain Reduction on Conditioned Pain Modulation in Adults: A Systematic Review.

Dorien Goubert et al.

Pain practice : the official journal of World Institute of Pain, 15(8), 765-777 (2014-11-13)

Pain facilitation as well as pain inhibition might be present in chronic pain patients. A decreased efficacy of pain inhibition can be measured by conditioned pain modulation (CPM). The use of the CPM paradigm in scientific research has boosted over

Direct evidence for the existence and functional role of hyperreactive sulfhydryls on the ryanodine receptor-triadin complex selectively labeled by the coumarin maleimide 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin.

G Liu et al.

Molecular pharmacology, 45(2), 189-200 (1994-02-01)

The fluorogenic sulfhydryl probe 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin (CPM) (1-50 nM) is used to characterize the functional role and location of highly reactive thiol groups on the ryanodine-sensitive Ca2+ release channel complex [i.e., ryanodine receptors (RyRs)] of skeletal and cardiac junctional sarcoplasmic reticulum

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货号	GTIN
C1484-25MG	04061833467626

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