C1484
7-二乙氨基-3-（4-马来酰亚胺苯基）-4-甲基香豆素
≥95% purity (HPLC), solid
别名:
1 H -吡咯-2,5-二酮，1-（4-（7-（二乙氨基）-4-甲基-2-氧代-2 H -1-苯并吡喃-3-基）苯基）-, CPM
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关于此项目
经验公式（希尔记法）:
C24H22N2O4
化学文摘社编号:
分子量:
402.44
MDL编号:
UNSPSC代码:
12171500
PubChem化学物质编号:
NACRES:
NA.47
产品名称
7-二乙氨基-3-（4-马来酰亚胺苯基）-4-甲基香豆素, ≥95% (HPLC), solid
质量水平
方案
≥95% (HPLC)
表单
solid
技术
titration: suitable
颜色
yellow
溶解性
DMSO: soluble
methanol: soluble
应用
diagnostic assay manufacturing
hematology
histology
储存温度
−20°C
SMILES字符串
CCN(CC)c1ccc2C(C)=C(C(=O)Oc2c1)c3ccc(cc3)N4C(=O)C=CC4=O
InChI
1S/C24H22N2O4/c1-4-25(5-2)18-10-11-19-15(3)23(24(29)30-20(19)14-18)16-6-8-17(9-7-16)26-21(27)12-13-22(26)28/h6-14H,4-5H2,1-3H3
InChI key
YGIABALXNBVHBX-UHFFFAOYSA-N
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一般描述
7-二乙氨基-3-（4-马来酸亚胺基苯基）-4-甲基香豆素（CPM）是具有高度荧光特性，含巯基（-SH）的香豆素衍生物。激发和发射波长分别为355 nm和460 nm。
应用
7-二乙氨基-3-（4-马来酸亚胺基苯基）-4-甲基香豆素用于：
- 作为无毒替代品，与抗体结合（93）
- 在人 N--肉豆蔻酰基转移酶测定中，辅助荧光检测辅酶A（CoA-SH）（94）
- 重组蛋白热稳定性转变测定（95）
生化/生理作用
用于监测硫醇的释放，定量微孔板反应中的硫醇，并通过核仁蛋白染色区分增殖的癌细胞。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Targeting Acyl-CoA: diacylglycerol acyltransferase 1 (DGAT1) with small molecule inhibitors for the treatment of metabolic diseases
Cao JS, et al.
The Journal of biological chemistry, 286(48), 41838-41851 (2011)
Dorien Goubert et al.
Pain practice : the official journal of World Institute of Pain, 15(8), 765-777 (2014-11-13)
Pain facilitation as well as pain inhibition might be present in chronic pain patients. A decreased efficacy of pain inhibition can be measured by conditioned pain modulation (CPM). The use of the CPM paradigm in scientific research has boosted over
Simple Futarmal Kothari et al.
Pain, 156(12), 2545-2555 (2015-08-27)
The pathophysiology and underlying pain mechanisms of temporomandibular disorders (TMD) are poorly understood. The aims were to assess somatosensory function at the temporomandibular joints (TMJs) and to examine whether conditioned pain modulation (CPM) differs between TMD pain patients (n =
G Liu et al.
Molecular pharmacology, 45(2), 189-200 (1994-02-01)
The fluorogenic sulfhydryl probe 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin (CPM) (1-50 nM) is used to characterize the functional role and location of highly reactive thiol groups on the ryanodine-sensitive Ca2+ release channel complex [i.e., ryanodine receptors (RyRs)] of skeletal and cardiac junctional sarcoplasmic reticulum
Tamara N Tsalkova et al.
Biochemistry, 46(1), 106-119 (2007-01-03)
Design of a partially cysteine-depleted C98S/C239S/C377S/C468A cytochrome P450 3A4 mutant designated CYP3A4(C58,C64) allowed site-directed incorporation of thiol-reactive fluorescent probes into alpha-helix A. The site of modification was identified as Cys-64 with the help of CYP3A4(C58) and CYP3A4(C64), each bearing only
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